TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1355c/moeY:

update plot	correlation	link to info on gene
Rv2582/ppiB	(cc=0.4993)	info on Rv2582/ppiB
Rv0070c/glyA2	(cc=0.4888)	info on Rv0070c/glyA2
Rv0048c/-	(cc=0.4622)	info on Rv0048c/-
Rv2548A/-	(cc=0.4537)	info on Rv2548A/-
Rv0669c/-	(cc=0.4531)	info on Rv0669c/-
Rv0938/ligD	(cc=0.4358)	info on Rv0938/ligD
Rv3529c/-	(cc=0.4319)	info on Rv3529c/-
Rv3840/-	(cc=0.4284)	info on Rv3840/-
Rv1616/-	(cc=0.427)	info on Rv1616/-
Rv2195/qcrA	(cc=0.4267)	info on Rv2195/qcrA

Correlation of Rv1355c/moeY with Rv1616/-

Normalized LFCs for Rv1355c/moeY:
(description and provenance of datasets)

	Rv1355c/moeY	Rv1616/-
Fe_supp_jason_reseq	-0.611	-0.396
low_pH_jason_reseq	0.586	-0.565
NO_jason_reseq	-0.735	0.48
B6_jason_reseq	0.15	-0.844
MHCII_jason_reseq	0.525	-0.966
Isoniazid02	0.0	1.371
Rifampicin4	-0.114	1.162
Ethambutol3	0.32	1.67
Meropenem3	0.187	1.185
Vancomycin16	0.414	1.398
Rv2680_day32	0.0	0.079
H37Rv_KO_MarP	-0.054	-1.139
hypoxia_3wks	0.626	1.766
hypoxia_6wks	-0.48	1.775
glycerol	-0.554	1.251
cholesterol	1.134	1.032
AJ	0.222	1.133
Bibs02	0.175	0.539
Bibs02c	-0.268	-0.621
BL6	0.143	1.823
BL6a	-0.082	1.778
BXD01	0.443	1.536
BXD010	0.889	2.447
BXD011	0.146	1.72
BXD03	0.499	2.456
BXD04	-0.276	1.862
BXD05	0.177	2.644
BXD06	0.176	2.342
BXD07	0.301	2.289
BXD08	-0.055	2.089
BXD09	0.373	2.112
CAST	-0.953	1.021
CCcont	-0.158	1.046
DS01	-0.469	0.524
DS02	-0.135	0.46
DS04	-0.249	1.712
DS0c	0.207	1.043
GP01	-0.196	1.749
GP02	0.705	1.063
GP0c	0.345	1.472
NOD	-0.737	-0.135
NZO	-0.04	1.017
PWK	0.857	1.576
H37Rv_KO_CtpC	-0.578	2.035
H37Rv_KO_CtpD	-0.106	0.541
H37Rv_KO_Rv1272	0.028	1.932
H37Rv_KO_SugABC	1.047	1.821
H37Rv_KO_MbtN	0.726	1.227
Trans05	-0.706	2.0
macrophage_unactivated	-0.398	0.073
IL1	-0.181	0.217
Rapamycin	-0.092	0.175
Tcell	0.098	0.684
GMCSF	-0.079	0.697
IFNab	-0.281	1.149
IFNg	-0.425	0.783
IFNg_GMCSF1	-0.396	0.449
Rv1432_day32	0.329	0.46
Rv1565c_day32	-0.188	-1.071
secA2_input	-0.667	-0.928
delta_Rv3594	-1.563	-0.578
delta_Rv3717	-1.232	-0.642
delta_Rv3811	-0.761	-0.61
delta_Rv0954	-1.627	-0.735
PonA1	-1.577	0.046
EccD1_KO	-1.273	0.418
EspI_KO	-0.799	-0.471
PE35_KO	-0.169	0.528
PPE68_KO	-0.186	0.224
glycerol2	0.297	-0.339
lignocerate	0.068	-1.159
oleate	0.829	1.606
phosphatidylcholine	0.514	-0.305
acetate	-0.489	-0.788
glucAc	-0.51	-0.999
Rv0950ko	0.476	0.32
Rv1096ko	0.549	-0.347
Rv3684ko	0.177	0.314
delta_otsA_trehalose	-1.986	-1.703