TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1355c/moeY:

update plot	correlation	link to info on gene
Rv2582/ppiB	(cc=0.4993)	info on Rv2582/ppiB
Rv0070c/glyA2	(cc=0.4888)	info on Rv0070c/glyA2
Rv0048c/-	(cc=0.4622)	info on Rv0048c/-
Rv2548A/-	(cc=0.4537)	info on Rv2548A/-
Rv0669c/-	(cc=0.4531)	info on Rv0669c/-
Rv0938/ligD	(cc=0.4358)	info on Rv0938/ligD
Rv3529c/-	(cc=0.4319)	info on Rv3529c/-
Rv3840/-	(cc=0.4284)	info on Rv3840/-
Rv1616/-	(cc=0.427)	info on Rv1616/-
Rv2195/qcrA	(cc=0.4267)	info on Rv2195/qcrA

Correlation of Rv1355c/moeY with Rv0070c/glyA2

Normalized LFCs for Rv1355c/moeY:
(description and provenance of datasets)

	Rv1355c/moeY	Rv0070c/glyA2
Fe_supp_jason_reseq	-0.611	-0.096
low_pH_jason_reseq	0.586	0.514
NO_jason_reseq	-0.735	-0.079
B6_jason_reseq	0.15	0.85
MHCII_jason_reseq	0.525	0.547
Isoniazid02	0.0	0.109
Rifampicin4	-0.114	-0.636
Ethambutol3	0.32	1.521
Meropenem3	0.187	-0.393
Vancomycin16	0.414	-0.172
Rv2680_day32	0.0	-0.947
H37Rv_KO_MarP	-0.054	0.185
hypoxia_3wks	0.626	-0.459
hypoxia_6wks	-0.48	-0.43
glycerol	-0.554	0.099
cholesterol	1.134	0.112
AJ	0.222	-0.17
Bibs02	0.175	0.305
Bibs02c	-0.268	0.65
BL6	0.143	1.125
BL6a	-0.082	0.616
BXD01	0.443	0.25
BXD010	0.889	0.407
BXD011	0.146	-0.193
BXD03	0.499	0.711
BXD04	-0.276	0.084
BXD05	0.177	0.438
BXD06	0.176	0.583
BXD07	0.301	0.578
BXD08	-0.055	0.642
BXD09	0.373	0.457
CAST	-0.953	-0.269
CCcont	-0.158	0.757
DS01	-0.469	0.27
DS02	-0.135	-0.23
DS04	-0.249	1.366
DS0c	0.207	0.207
GP01	-0.196	1.157
GP02	0.705	0.806
GP0c	0.345	0.354
NOD	-0.737	-0.473
NZO	-0.04	-0.627
PWK	0.857	0.473
H37Rv_KO_CtpC	-0.578	0.455
H37Rv_KO_CtpD	-0.106	0.458
H37Rv_KO_Rv1272	0.028	0.042
H37Rv_KO_SugABC	1.047	0.728
H37Rv_KO_MbtN	0.726	-0.879
Trans05	-0.706	0.114
macrophage_unactivated	-0.398	0.271
IL1	-0.181	0.314
Rapamycin	-0.092	0.448
Tcell	0.098	0.108
GMCSF	-0.079	0.029
IFNab	-0.281	0.59
IFNg	-0.425	0.115
IFNg_GMCSF1	-0.396	0.99
Rv1432_day32	0.329	0.353
Rv1565c_day32	-0.188	-0.017
secA2_input	-0.667	-0.288
delta_Rv3594	-1.563	-1.836
delta_Rv3717	-1.232	-1.057
delta_Rv3811	-0.761	-1.249
delta_Rv0954	-1.627	-1.186
PonA1	-1.577	-0.884
EccD1_KO	-1.273	-0.941
EspI_KO	-0.799	-0.662
PE35_KO	-0.169	0.193
PPE68_KO	-0.186	-0.259
glycerol2	0.297	0.643
lignocerate	0.068	0.392
oleate	0.829	0.257
phosphatidylcholine	0.514	0.422
acetate	-0.489	0.733
glucAc	-0.51	0.901
Rv0950ko	0.476	0.507
Rv1096ko	0.549	1.104
Rv3684ko	0.177	0.55
delta_otsA_trehalose	-1.986	-0.039