TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1355c/moeY:

update plot	correlation	link to info on gene
Rv2582/ppiB	(cc=0.4993)	info on Rv2582/ppiB
Rv0070c/glyA2	(cc=0.4888)	info on Rv0070c/glyA2
Rv0048c/-	(cc=0.4622)	info on Rv0048c/-
Rv2548A/-	(cc=0.4537)	info on Rv2548A/-
Rv0669c/-	(cc=0.4531)	info on Rv0669c/-
Rv0938/ligD	(cc=0.4358)	info on Rv0938/ligD
Rv3529c/-	(cc=0.4319)	info on Rv3529c/-
Rv3840/-	(cc=0.4284)	info on Rv3840/-
Rv1616/-	(cc=0.427)	info on Rv1616/-
Rv2195/qcrA	(cc=0.4267)	info on Rv2195/qcrA

Correlation of Rv1355c/moeY with Rv0669c/-

Normalized LFCs for Rv1355c/moeY:
(description and provenance of datasets)

	Rv1355c/moeY	Rv0669c/-
Fe_supp_jason_reseq	-0.611	-0.156
low_pH_jason_reseq	0.586	-0.582
NO_jason_reseq	-0.735	0.039
B6_jason_reseq	0.15	0.331
MHCII_jason_reseq	0.525	0.163
Isoniazid02	0.0	0.247
Rifampicin4	-0.114	0.0
Ethambutol3	0.32	1.07
Meropenem3	0.187	0.492
Vancomycin16	0.414	-0.019
Rv2680_day32	0.0	0.483
H37Rv_KO_MarP	-0.054	0.344
hypoxia_3wks	0.626	-0.231
hypoxia_6wks	-0.48	0.092
glycerol	-0.554	0.445
cholesterol	1.134	3.252
AJ	0.222	0.279
Bibs02	0.175	0.317
Bibs02c	-0.268	-0.03
BL6	0.143	-0.03
BL6a	-0.082	-0.135
BXD01	0.443	0.134
BXD010	0.889	-0.056
BXD011	0.146	0.12
BXD03	0.499	0.318
BXD04	-0.276	0.164
BXD05	0.177	0.121
BXD06	0.176	0.155
BXD07	0.301	0.013
BXD08	-0.055	0.209
BXD09	0.373	-0.161
CAST	-0.953	0.237
CCcont	-0.158	-0.276
DS01	-0.469	0.212
DS02	-0.135	0.386
DS04	-0.249	0.513
DS0c	0.207	0.138
GP01	-0.196	0.31
GP02	0.705	-0.395
GP0c	0.345	-0.135
NOD	-0.737	0.251
NZO	-0.04	0.247
PWK	0.857	0.269
H37Rv_KO_CtpC	-0.578	-0.127
H37Rv_KO_CtpD	-0.106	0.199
H37Rv_KO_Rv1272	0.028	0.534
H37Rv_KO_SugABC	1.047	1.096
H37Rv_KO_MbtN	0.726	-0.03
Trans05	-0.706	-0.076
macrophage_unactivated	-0.398	-0.174
IL1	-0.181	-0.486
Rapamycin	-0.092	-0.718
Tcell	0.098	0.042
GMCSF	-0.079	-0.09
IFNab	-0.281	-0.405
IFNg	-0.425	-0.521
IFNg_GMCSF1	-0.396	-0.493
Rv1432_day32	0.329	0.183
Rv1565c_day32	-0.188	-0.22
secA2_input	-0.667	-1.021
delta_Rv3594	-1.563	-0.32
delta_Rv3717	-1.232	-0.322
delta_Rv3811	-0.761	-0.103
delta_Rv0954	-1.627	-0.91
PonA1	-1.577	-0.372
EccD1_KO	-1.273	0.385
EspI_KO	-0.799	0.642
PE35_KO	-0.169	0.076
PPE68_KO	-0.186	0.163
glycerol2	0.297	0.815
lignocerate	0.068	0.919
oleate	0.829	0.333
phosphatidylcholine	0.514	0.944
acetate	-0.489	0.532
glucAc	-0.51	0.573
Rv0950ko	0.476	0.265
Rv1096ko	0.549	0.066
Rv3684ko	0.177	0.265
delta_otsA_trehalose	-1.986	-1.542