TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1275/lprC:

update plot	correlation	link to info on gene
Rv3245c/mtrB	(cc=0.6637)	info on Rv3245c/mtrB
Rv2603c/-	(cc=0.6198)	info on Rv2603c/-
Rv0011c/-	(cc=0.5873)	info on Rv0011c/-
Rv2965c/kdtB	(cc=0.5736)	info on Rv2965c/kdtB
Rv1636/TB15.3	(cc=0.571)	info on Rv1636/TB15.3
Rv0651/rplJ	(cc=0.5665)	info on Rv0651/rplJ
Rv0127/mak	(cc=0.5496)	info on Rv0127/mak
Rv2837c/-	(cc=0.5422)	info on Rv2837c/-
Rv2869c/rip	(cc=0.5393)	info on Rv2869c/rip
Rv3102c/ftsE	(cc=0.5381)	info on Rv3102c/ftsE

Correlation of Rv1275/lprC with Rv3245c/mtrB

Normalized LFCs for Rv1275/lprC:
(description and provenance of datasets)

	Rv1275/lprC	Rv3245c/mtrB
Fe_supp_jason_reseq	0.218	0.218
low_pH_jason_reseq	0.0	0.0
NO_jason_reseq	0.0	0.0
B6_jason_reseq	0.0	0.0
MHCII_jason_reseq	0.0	0.0
Isoniazid02	0.0	0.0
Rifampicin4	0.0	0.0
Ethambutol3	0.0	0.0
Meropenem3	0.0	0.0
Vancomycin16	0.0	0.0
Rv2680_day32	0.0	0.0
H37Rv_KO_MarP	-2.194	-0.371
hypoxia_3wks	0.0	0.0
hypoxia_6wks	0.0	0.0
glycerol	0.0	0.0
cholesterol	0.0	0.0
AJ	0.0	0.0
Bibs02	0.0	0.0
Bibs02c	0.0	0.0
BL6	0.0	0.0
BL6a	0.0	0.0
BXD01	0.0	0.0
BXD010	0.0	0.0
BXD011	1.05	0.0
BXD03	0.0	0.0
BXD04	0.0	0.0
BXD05	0.0	0.0
BXD06	0.0	0.0
BXD07	0.0	0.0
BXD08	0.0	0.0
BXD09	0.0	0.0
CAST	0.0	0.0
CCcont	0.285	0.0
DS01	0.0	0.0
DS02	0.0	0.0
DS04	0.533	0.0
DS0c	0.0	0.0
GP01	0.0	0.0
GP02	0.0	0.0
GP0c	0.0	0.0
NOD	0.0	0.0
NZO	0.0	0.0
PWK	0.0	0.0
H37Rv_KO_CtpC	0.162	0.0
H37Rv_KO_CtpD	0.0	0.0
H37Rv_KO_Rv1272	0.141	0.0
H37Rv_KO_SugABC	0.189	0.0
H37Rv_KO_MbtN	0.283	0.0
Trans05	0.0	0.0
macrophage_unactivated	0.0	0.0
IL1	0.0	0.0
Rapamycin	0.0	0.0
Tcell	0.0	0.0
GMCSF	0.0	0.0
IFNab	0.0	0.0
IFNg	0.0	0.0
IFNg_GMCSF1	0.0	0.0
Rv1432_day32	0.0	0.0
Rv1565c_day32	0.0	0.0
secA2_input	3.042	1.65
delta_Rv3594	2.362	0.0
delta_Rv3717	-0.331	0.0
delta_Rv3811	0.986	0.0
delta_Rv0954	-0.34	0.0
PonA1	-0.304	0.0
EccD1_KO	0.474	0.0
EspI_KO	0.211	0.0
PE35_KO	0.42	1.105
PPE68_KO	1.789	0.841
glycerol2	0.0	0.0
lignocerate	0.0	0.0
oleate	0.0	0.0
phosphatidylcholine	0.0	0.0
acetate	0.0	0.0
glucAc	0.0	0.0
Rv0950ko	-0.534	0.0
Rv1096ko	-0.929	0.0
Rv3684ko	0.177	0.452
delta_otsA_trehalose	0.0	0.0