TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1035c/-:

update plot	correlation	link to info on gene
Rv0150c/-	(cc=0.5665)	info on Rv0150c/-
Rv2585c/-	(cc=0.5171)	info on Rv2585c/-
Rv1767/-	(cc=0.5114)	info on Rv1767/-
Rv1897c/-	(cc=0.4643)	info on Rv1897c/-
Rv1363c/-	(cc=0.4458)	info on Rv1363c/-
Rv2549c/vapC20	(cc=0.4271)	info on Rv2549c/vapC20
Rv1486c/-	(cc=0.422)	info on Rv1486c/-
Rv2806/-	(cc=0.4212)	info on Rv2806/-
Rv2231c/cobC	(cc=0.4195)	info on Rv2231c/cobC
Rv2129c/-	(cc=0.419)	info on Rv2129c/-

Correlation of Rv1035c/- with Rv2231c/cobC

Normalized LFCs for Rv1035c/-:
(description and provenance of datasets)

	Rv1035c/-	Rv2231c/cobC
Fe_supp_jason_reseq	0.264	-0.463
low_pH_jason_reseq	-1.723	-0.1
NO_jason_reseq	-0.239	-0.079
B6_jason_reseq	-0.285	-1.435
MHCII_jason_reseq	-0.151	-0.893
Isoniazid02	-1.037	-0.581
Rifampicin4	0.227	0.133
Ethambutol3	-0.755	-0.158
Meropenem3	2.125	-0.363
Vancomycin16	-0.488	-0.568
Rv2680_day32	1.306	0.811
H37Rv_KO_MarP	-0.906	-1.507
hypoxia_3wks	-0.227	0.467
hypoxia_6wks	-0.558	1.205
glycerol	0.208	0.162
cholesterol	1.439	-0.264
AJ	1.321	-0.424
Bibs02	2.307	0.946
Bibs02c	-2.12	-0.182
BL6	-1.392	0.477
BL6a	0.91	1.122
BXD01	0.331	1.214
BXD010	1.179	0.629
BXD011	0.045	1.498
BXD03	1.519	1.088
BXD04	-0.299	2.739
BXD05	2.665	1.863
BXD06	0.483	1.947
BXD07	1.003	1.383
BXD08	0.811	2.292
BXD09	0.318	1.614
CAST	1.54	-0.791
CCcont	-1.662	1.202
DS01	-1.177	0.0
DS02	0.841	-0.189
DS04	0.936	-0.453
DS0c	-1.211	1.383
GP01	-0.383	0.0
GP02	2.29	-0.286
GP0c	0.134	-0.113
NOD	0.231	-0.905
NZO	0.722	1.225
PWK	0.136	-0.171
H37Rv_KO_CtpC	-0.186	0.571
H37Rv_KO_CtpD	-1.409	-0.591
H37Rv_KO_Rv1272	1.477	1.338
H37Rv_KO_SugABC	-0.754	0.586
H37Rv_KO_MbtN	0.608	1.226
Trans05	2.581	1.536
macrophage_unactivated	1.764	1.922
IL1	0.359	1.139
Rapamycin	1.715	1.669
Tcell	0.163	1.189
GMCSF	3.369	1.014
IFNab	0.834	0.683
IFNg	0.198	0.82
IFNg_GMCSF1	2.02	1.546
Rv1432_day32	0.0	-0.618
Rv1565c_day32	-0.082	-1.989
secA2_input	-1.832	-0.62
delta_Rv3594	1.825	2.709
delta_Rv3717	2.901	2.718
delta_Rv3811	3.004	2.314
delta_Rv0954	1.919	1.773
PonA1	-2.086	1.506
EccD1_KO	-0.96	0.201
EspI_KO	-0.833	-0.787
PE35_KO	-0.181	0.265
PPE68_KO	-1.808	0.099
glycerol2	-1.115	0.0
lignocerate	-1.801	0.082
oleate	-0.474	0.539
phosphatidylcholine	-1.039	0.213
acetate	-3.125	-0.283
glucAc	-3.31	-0.405
Rv0950ko	0.211	0.395
Rv1096ko	1.306	0.202
Rv3684ko	0.861	0.0
delta_otsA_trehalose	-0.77	0.58