TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1035c/-:

update plot	correlation	link to info on gene
Rv0150c/-	(cc=0.5665)	info on Rv0150c/-
Rv2585c/-	(cc=0.5171)	info on Rv2585c/-
Rv1767/-	(cc=0.5114)	info on Rv1767/-
Rv1897c/-	(cc=0.4643)	info on Rv1897c/-
Rv1363c/-	(cc=0.4458)	info on Rv1363c/-
Rv2549c/vapC20	(cc=0.4271)	info on Rv2549c/vapC20
Rv1486c/-	(cc=0.422)	info on Rv1486c/-
Rv2806/-	(cc=0.4212)	info on Rv2806/-
Rv2231c/cobC	(cc=0.4195)	info on Rv2231c/cobC
Rv2129c/-	(cc=0.419)	info on Rv2129c/-

Correlation of Rv1035c/- with Rv1767/-

Normalized LFCs for Rv1035c/-:
(description and provenance of datasets)

	Rv1035c/-	Rv1767/-
Fe_supp_jason_reseq	0.264	0.039
low_pH_jason_reseq	-1.723	-0.979
NO_jason_reseq	-0.239	0.528
B6_jason_reseq	-0.285	-0.67
MHCII_jason_reseq	-0.151	-0.553
Isoniazid02	-1.037	0.207
Rifampicin4	0.227	0.236
Ethambutol3	-0.755	0.753
Meropenem3	2.125	0.035
Vancomycin16	-0.488	-0.162
Rv2680_day32	1.306	-0.363
H37Rv_KO_MarP	-0.906	0.113
hypoxia_3wks	-0.227	-0.881
hypoxia_6wks	-0.558	-0.912
glycerol	0.208	0.949
cholesterol	1.439	-0.57
AJ	1.321	0.499
Bibs02	2.307	1.48
Bibs02c	-2.12	-0.383
BL6	-1.392	0.832
BL6a	0.91	0.426
BXD01	0.331	-0.108
BXD010	1.179	0.465
BXD011	0.045	1.117
BXD03	1.519	0.071
BXD04	-0.299	-0.033
BXD05	2.665	0.602
BXD06	0.483	0.167
BXD07	1.003	0.394
BXD08	0.811	-0.258
BXD09	0.318	-0.051
CAST	1.54	0.496
CCcont	-1.662	-0.53
DS01	-1.177	-0.587
DS02	0.841	0.706
DS04	0.936	0.101
DS0c	-1.211	-1.216
GP01	-0.383	0.268
GP02	2.29	2.154
GP0c	0.134	1.155
NOD	0.231	0.368
NZO	0.722	0.737
PWK	0.136	-0.2
H37Rv_KO_CtpC	-0.186	-0.315
H37Rv_KO_CtpD	-1.409	-0.117
H37Rv_KO_Rv1272	1.477	0.748
H37Rv_KO_SugABC	-0.754	-0.054
H37Rv_KO_MbtN	0.608	-0.019
Trans05	2.581	0.592
macrophage_unactivated	1.764	0.385
IL1	0.359	-0.558
Rapamycin	1.715	-0.184
Tcell	0.163	-0.723
GMCSF	3.369	0.026
IFNab	0.834	-0.339
IFNg	0.198	-0.535
IFNg_GMCSF1	2.02	0.06
Rv1432_day32	0.0	0.383
Rv1565c_day32	-0.082	1.232
secA2_input	-1.832	-2.855
delta_Rv3594	1.825	1.638
delta_Rv3717	2.901	1.457
delta_Rv3811	3.004	2.045
delta_Rv0954	1.919	1.659
PonA1	-2.086	-0.95
EccD1_KO	-0.96	0.109
EspI_KO	-0.833	1.56
PE35_KO	-0.181	-0.516
PPE68_KO	-1.808	0.07
glycerol2	-1.115	-1.211
lignocerate	-1.801	-0.408
oleate	-0.474	-0.498
phosphatidylcholine	-1.039	-0.424
acetate	-3.125	0.166
glucAc	-3.31	-0.416
Rv0950ko	0.211	0.694
Rv1096ko	1.306	0.477
Rv3684ko	0.861	1.945
delta_otsA_trehalose	-0.77	-0.994