TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0926c/-:

update plot	correlation	link to info on gene
Rv2849c/cobO	(cc=0.5293)	info on Rv2849c/cobO
Rv3678c/-	(cc=0.4791)	info on Rv3678c/-
Rv2737A/-	(cc=0.4584)	info on Rv2737A/-
Rv3636/-	(cc=0.4461)	info on Rv3636/-
Rv0380c/-	(cc=0.4344)	info on Rv0380c/-
Rv0619/galTb	(cc=0.4336)	info on Rv0619/galTb
Rv1234/-	(cc=0.4304)	info on Rv1234/-
Rv0740/-	(cc=0.4291)	info on Rv0740/-
Rv1131/prpC	(cc=0.4282)	info on Rv1131/prpC
Rv0500/proC	(cc=0.4228)	info on Rv0500/proC

Correlation of Rv0926c/- with Rv3636/-

Normalized LFCs for Rv0926c/-:
(description and provenance of datasets)

	Rv0926c/-	Rv3636/-
Fe_supp_jason_reseq	0.06	0.559
low_pH_jason_reseq	0.519	-0.032
NO_jason_reseq	0.05	1.391
B6_jason_reseq	-0.357	0.093
MHCII_jason_reseq	0.709	0.991
Isoniazid02	0.895	0.288
Rifampicin4	0.761	0.707
Ethambutol3	0.927	0.136
Meropenem3	0.022	1.744
Vancomycin16	0.414	0.875
Rv2680_day32	-1.629	-2.621
H37Rv_KO_MarP	0.12	0.831
hypoxia_3wks	-0.104	0.315
hypoxia_6wks	-1.303	-0.453
glycerol	0.63	1.059
cholesterol	0.111	-0.057
AJ	-0.629	0.977
Bibs02	-0.391	-0.766
Bibs02c	-0.899	-0.418
BL6	0.28	-0.488
BL6a	0.274	-0.284
BXD01	0.015	0.873
BXD010	0.814	0.852
BXD011	0.753	0.591
BXD03	0.79	-0.509
BXD04	0.552	-0.012
BXD05	0.443	0.331
BXD06	0.634	0.349
BXD07	0.638	0.864
BXD08	0.298	0.585
BXD09	0.414	0.336
CAST	0.474	-0.232
CCcont	0.621	-0.231
DS01	-0.224	0.195
DS02	-0.347	0.274
DS04	-0.388	0.357
DS0c	-0.493	-0.385
GP01	-1.476	-0.386
GP02	-0.641	0.451
GP0c	-0.451	0.798
NOD	-0.132	-1.362
NZO	0.131	1.445
PWK	0.108	1.017
H37Rv_KO_CtpC	0.918	0.246
H37Rv_KO_CtpD	-0.015	0.36
H37Rv_KO_Rv1272	0.25	0.909
H37Rv_KO_SugABC	0.672	0.206
H37Rv_KO_MbtN	-0.657	0.407
Trans05	0.862	1.694
macrophage_unactivated	0.35	-0.041
IL1	0.353	0.62
Rapamycin	0.838	0.979
Tcell	-0.088	0.492
GMCSF	1.278	0.301
IFNab	0.623	-0.248
IFNg	1.243	0.853
IFNg_GMCSF1	1.81	1.295
Rv1432_day32	0.0	-0.18
Rv1565c_day32	-0.112	0.329
secA2_input	0.556	-0.675
delta_Rv3594	0.359	-1.104
delta_Rv3717	-0.272	-0.106
delta_Rv3811	0.0	-0.462
delta_Rv0954	0.457	0.49
PonA1	-0.431	-0.021
EccD1_KO	-0.724	-0.335
EspI_KO	0.242	0.251
PE35_KO	-0.403	0.172
PPE68_KO	-0.442	0.096
glycerol2	0.113	0.097
lignocerate	-0.196	-0.077
oleate	-0.364	0.62
phosphatidylcholine	-0.204	0.06
acetate	-0.023	-0.432
glucAc	0.056	-0.582
Rv0950ko	1.067	0.938
Rv1096ko	0.754	2.129
Rv3684ko	0.684	1.634
delta_otsA_trehalose	-0.311	-1.138