TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0926c/-:

update plot	correlation	link to info on gene
Rv2849c/cobO	(cc=0.5293)	info on Rv2849c/cobO
Rv3678c/-	(cc=0.4791)	info on Rv3678c/-
Rv2737A/-	(cc=0.4584)	info on Rv2737A/-
Rv3636/-	(cc=0.4461)	info on Rv3636/-
Rv0380c/-	(cc=0.4344)	info on Rv0380c/-
Rv0619/galTb	(cc=0.4336)	info on Rv0619/galTb
Rv1234/-	(cc=0.4304)	info on Rv1234/-
Rv0740/-	(cc=0.4291)	info on Rv0740/-
Rv1131/prpC	(cc=0.4282)	info on Rv1131/prpC
Rv0500/proC	(cc=0.4228)	info on Rv0500/proC

Correlation of Rv0926c/- with Rv0500/proC

Normalized LFCs for Rv0926c/-:
(description and provenance of datasets)

	Rv0926c/-	Rv0500/proC
Fe_supp_jason_reseq	0.06	-0.415
low_pH_jason_reseq	0.519	-0.44
NO_jason_reseq	0.05	0.583
B6_jason_reseq	-0.357	-0.292
MHCII_jason_reseq	0.709	-0.257
Isoniazid02	0.895	0.0
Rifampicin4	0.761	-0.341
Ethambutol3	0.927	-0.153
Meropenem3	0.022	0.497
Vancomycin16	0.414	-0.698
Rv2680_day32	-1.629	0.0
H37Rv_KO_MarP	0.12	0.553
hypoxia_3wks	-0.104	-1.388
hypoxia_6wks	-1.303	-1.013
glycerol	0.63	0.0
cholesterol	0.111	0.0
AJ	-0.629	0.0
Bibs02	-0.391	0.0
Bibs02c	-0.899	0.0
BL6	0.28	0.0
BL6a	0.274	0.973
BXD01	0.015	0.0
BXD010	0.814	0.543
BXD011	0.753	0.35
BXD03	0.79	0.907
BXD04	0.552	0.236
BXD05	0.443	0.975
BXD06	0.634	0.469
BXD07	0.638	0.851
BXD08	0.298	1.096
BXD09	0.414	1.753
CAST	0.474	0.0
CCcont	0.621	0.0
DS01	-0.224	0.0
DS02	-0.347	0.0
DS04	-0.388	0.0
DS0c	-0.493	0.0
GP01	-1.476	0.0
GP02	-0.641	0.0
GP0c	-0.451	0.0
NOD	-0.132	0.0
NZO	0.131	0.0
PWK	0.108	0.0
H37Rv_KO_CtpC	0.918	0.0
H37Rv_KO_CtpD	-0.015	0.0
H37Rv_KO_Rv1272	0.25	0.0
H37Rv_KO_SugABC	0.672	0.0
H37Rv_KO_MbtN	-0.657	0.0
Trans05	0.862	0.131
macrophage_unactivated	0.35	0.884
IL1	0.353	-0.658
Rapamycin	0.838	0.0
Tcell	-0.088	-0.349
GMCSF	1.278	0.0
IFNab	0.623	0.0
IFNg	1.243	1.376
IFNg_GMCSF1	1.81	1.386
Rv1432_day32	0.0	0.0
Rv1565c_day32	-0.112	0.0
secA2_input	0.556	0.545
delta_Rv3594	0.359	0.211
delta_Rv3717	-0.272	0.174
delta_Rv3811	0.0	0.721
delta_Rv0954	0.457	0.627
PonA1	-0.431	0.437
EccD1_KO	-0.724	-1.273
EspI_KO	0.242	0.87
PE35_KO	-0.403	-1.129
PPE68_KO	-0.442	-0.579
glycerol2	0.113	-0.369
lignocerate	-0.196	-0.32
oleate	-0.364	-0.373
phosphatidylcholine	-0.204	-0.368
acetate	-0.023	-0.437
glucAc	0.056	-0.272
Rv0950ko	1.067	1.049
Rv1096ko	0.754	0.38
Rv3684ko	0.684	-0.452
delta_otsA_trehalose	-0.311	-0.133