TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0926c/-:

update plot	correlation	link to info on gene
Rv2849c/cobO	(cc=0.5293)	info on Rv2849c/cobO
Rv3678c/-	(cc=0.4791)	info on Rv3678c/-
Rv2737A/-	(cc=0.4584)	info on Rv2737A/-
Rv3636/-	(cc=0.4461)	info on Rv3636/-
Rv0380c/-	(cc=0.4344)	info on Rv0380c/-
Rv0619/galTb	(cc=0.4336)	info on Rv0619/galTb
Rv1234/-	(cc=0.4304)	info on Rv1234/-
Rv0740/-	(cc=0.4291)	info on Rv0740/-
Rv1131/prpC	(cc=0.4282)	info on Rv1131/prpC
Rv0500/proC	(cc=0.4228)	info on Rv0500/proC

Correlation of Rv0926c/- with Rv0740/-

Normalized LFCs for Rv0926c/-:
(description and provenance of datasets)

	Rv0926c/-	Rv0740/-
Fe_supp_jason_reseq	0.06	0.069
low_pH_jason_reseq	0.519	1.802
NO_jason_reseq	0.05	0.774
B6_jason_reseq	-0.357	1.02
MHCII_jason_reseq	0.709	0.233
Isoniazid02	0.895	0.989
Rifampicin4	0.761	0.087
Ethambutol3	0.927	1.16
Meropenem3	0.022	0.688
Vancomycin16	0.414	0.17
Rv2680_day32	-1.629	-1.013
H37Rv_KO_MarP	0.12	-0.027
hypoxia_3wks	-0.104	-1.854
hypoxia_6wks	-1.303	-1.063
glycerol	0.63	-1.09
cholesterol	0.111	-0.158
AJ	-0.629	-0.345
Bibs02	-0.391	-0.901
Bibs02c	-0.899	-0.203
BL6	0.28	0.712
BL6a	0.274	0.089
BXD01	0.015	0.428
BXD010	0.814	-0.781
BXD011	0.753	0.235
BXD03	0.79	0.197
BXD04	0.552	0.826
BXD05	0.443	0.525
BXD06	0.634	0.031
BXD07	0.638	0.557
BXD08	0.298	0.465
BXD09	0.414	-0.218
CAST	0.474	0.566
CCcont	0.621	0.195
DS01	-0.224	0.296
DS02	-0.347	0.147
DS04	-0.388	0.358
DS0c	-0.493	0.347
GP01	-1.476	-1.157
GP02	-0.641	-0.877
GP0c	-0.451	-0.753
NOD	-0.132	0.039
NZO	0.131	-1.503
PWK	0.108	-0.215
H37Rv_KO_CtpC	0.918	-1.662
H37Rv_KO_CtpD	-0.015	0.264
H37Rv_KO_Rv1272	0.25	-0.317
H37Rv_KO_SugABC	0.672	-0.969
H37Rv_KO_MbtN	-0.657	-0.706
Trans05	0.862	-0.284
macrophage_unactivated	0.35	1.925
IL1	0.353	0.406
Rapamycin	0.838	1.178
Tcell	-0.088	-0.147
GMCSF	1.278	0.689
IFNab	0.623	0.29
IFNg	1.243	1.267
IFNg_GMCSF1	1.81	3.02
Rv1432_day32	0.0	-0.222
Rv1565c_day32	-0.112	-1.579
secA2_input	0.556	-1.105
delta_Rv3594	0.359	-1.444
delta_Rv3717	-0.272	-0.789
delta_Rv3811	0.0	-1.022
delta_Rv0954	0.457	0.15
PonA1	-0.431	-0.668
EccD1_KO	-0.724	-0.141
EspI_KO	0.242	0.0
PE35_KO	-0.403	0.216
PPE68_KO	-0.442	0.186
glycerol2	0.113	-0.129
lignocerate	-0.196	0.0
oleate	-0.364	-1.602
phosphatidylcholine	-0.204	-0.384
acetate	-0.023	0.69
glucAc	0.056	0.868
Rv0950ko	1.067	-0.292
Rv1096ko	0.754	0.407
Rv3684ko	0.684	-0.183
delta_otsA_trehalose	-0.311	-0.138