TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0797/-:

update plot	correlation	link to info on gene
Rv3327/-	(cc=0.6362)	info on Rv3327/-
Rv2701c/suhB	(cc=0.5058)	info on Rv2701c/suhB
Rv0039c/-	(cc=0.4582)	info on Rv0039c/-
Rv0095c/-	(cc=0.4567)	info on Rv0095c/-
Rv2859c/-	(cc=0.4407)	info on Rv2859c/-
Rv2715/-	(cc=0.4327)	info on Rv2715/-
Rv1935c/echA13	(cc=0.429)	info on Rv1935c/echA13
Rv2043c/pncA	(cc=0.4214)	info on Rv2043c/pncA
Rv2124c/metH	(cc=0.4191)	info on Rv2124c/metH
Rv1562c/treZ	(cc=0.3978)	info on Rv1562c/treZ

Correlation of Rv0797/- with Rv0095c/-

Normalized LFCs for Rv0797/-:
(description and provenance of datasets)

	Rv0797/-	Rv0095c/-
Fe_supp_jason_reseq	-0.488	-1.579
low_pH_jason_reseq	0.877	0.328
NO_jason_reseq	0.018	0.583
B6_jason_reseq	0.073	-0.649
MHCII_jason_reseq	0.285	1.372
Isoniazid02	0.294	-0.227
Rifampicin4	0.866	0.195
Ethambutol3	0.522	0.0
Meropenem3	1.577	0.285
Vancomycin16	0.748	0.098
Rv2680_day32	0.23	0.0
H37Rv_KO_MarP	-0.023	-0.401
hypoxia_3wks	0.451	0.203
hypoxia_6wks	-0.119	-0.727
glycerol	-0.622	1.264
cholesterol	1.999	0.907
AJ	-0.234	-0.333
Bibs02	-0.101	0.657
Bibs02c	0.452	-0.056
BL6	0.784	0.819
BL6a	0.367	-0.409
BXD01	0.379	-1.604
BXD010	-0.02	-1.279
BXD011	-0.15	-0.646
BXD03	0.007	-0.279
BXD04	-0.047	-0.999
BXD05	0.685	0.349
BXD06	0.174	-0.32
BXD07	0.64	-0.533
BXD08	0.102	-0.619
BXD09	0.059	0.305
CAST	0.267	-0.475
CCcont	0.316	-0.41
DS01	0.406	0.662
DS02	-0.107	0.0
DS04	0.611	0.623
DS0c	-0.156	0.859
GP01	-0.333	-0.986
GP02	0.44	-0.672
GP0c	-0.028	-0.659
NOD	0.151	-0.322
NZO	-0.189	1.549
PWK	0.264	1.34
H37Rv_KO_CtpC	0.358	-2.31
H37Rv_KO_CtpD	0.079	-1.56
H37Rv_KO_Rv1272	-0.812	-2.005
H37Rv_KO_SugABC	0.601	1.894
H37Rv_KO_MbtN	-0.459	-1.363
Trans05	-0.365	-1.728
macrophage_unactivated	-0.18	-0.937
IL1	0.142	-1.133
Rapamycin	0.371	-1.172
Tcell	-0.456	-0.707
GMCSF	0.055	-0.573
IFNab	-0.444	-2.195
IFNg	0.219	0.425
IFNg_GMCSF1	0.258	0.5
Rv1432_day32	0.482	0.0
Rv1565c_day32	-0.161	0.599
secA2_input	-0.441	-1.947
delta_Rv3594	-0.548	0.133
delta_Rv3717	0.522	1.521
delta_Rv3811	0.192	0.583
delta_Rv0954	0.132	0.506
PonA1	0.376	0.372
EccD1_KO	0.701	0.454
EspI_KO	1.001	1.081
PE35_KO	0.828	1.706
PPE68_KO	0.477	2.022
glycerol2	-0.071	-0.68
lignocerate	0.06	0.0
oleate	-0.391	-0.688
phosphatidylcholine	0.008	-0.487
acetate	0.605	0.973
glucAc	0.172	0.199
Rv0950ko	0.178	-0.178
Rv1096ko	1.393	0.335
Rv3684ko	0.871	0.187
delta_otsA_trehalose	2.102	0.906