TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0774c/-:

update plot	correlation	link to info on gene
Rv3365c/-	(cc=0.5138)	info on Rv3365c/-
Rv0354c/PPE7	(cc=0.4637)	info on Rv0354c/PPE7
Rv0811c/-	(cc=0.4382)	info on Rv0811c/-
Rv0194/-	(cc=0.4352)	info on Rv0194/-
Rv2882c/frr	(cc=0.4327)	info on Rv2882c/frr
Rv0232/-	(cc=0.4294)	info on Rv0232/-
Rv0276/-	(cc=0.4269)	info on Rv0276/-
Rv0701/rplC	(cc=0.4177)	info on Rv0701/rplC
Rv0033/acpA	(cc=0.4176)	info on Rv0033/acpA
Rv0301/vapC2	(cc=0.4167)	info on Rv0301/vapC2

Correlation of Rv0774c/- with Rv0276/-

Normalized LFCs for Rv0774c/-:
(description and provenance of datasets)

	Rv0774c/-	Rv0276/-
Fe_supp_jason_reseq	-0.415	-0.807
low_pH_jason_reseq	-0.621	-0.855
NO_jason_reseq	-0.129	-0.113
B6_jason_reseq	-0.731	0.322
MHCII_jason_reseq	-0.818	0.118
Isoniazid02	-1.125	0.141
Rifampicin4	0.902	-0.23
Ethambutol3	-0.918	0.238
Meropenem3	-0.926	-0.272
Vancomycin16	0.273	0.478
Rv2680_day32	1.947	0.73
H37Rv_KO_MarP	-0.291	0.452
hypoxia_3wks	-0.311	-0.12
hypoxia_6wks	-0.04	-0.194
glycerol	-0.443	-0.297
cholesterol	0.378	0.193
AJ	-1.0	0.277
Bibs02	0.101	0.335
Bibs02c	0.252	0.108
BL6	0.576	0.3
BL6a	0.359	0.112
BXD01	0.054	-0.035
BXD010	0.035	-0.135
BXD011	-0.193	0.347
BXD03	0.292	-0.241
BXD04	0.44	0.613
BXD05	-0.368	0.451
BXD06	-0.118	-0.164
BXD07	0.234	0.421
BXD08	0.16	-0.287
BXD09	-0.19	0.142
CAST	1.261	0.619
CCcont	-0.251	-0.211
DS01	0.816	0.525
DS02	0.419	0.714
DS04	1.779	0.177
DS0c	-0.514	0.187
GP01	1.076	0.094
GP02	0.963	-1.435
GP0c	0.501	-0.51
NOD	-0.164	1.435
NZO	-0.087	-0.075
PWK	0.904	0.746
H37Rv_KO_CtpC	0.673	0.067
H37Rv_KO_CtpD	1.117	-0.282
H37Rv_KO_Rv1272	-1.19	0.195
H37Rv_KO_SugABC	-1.408	-0.128
H37Rv_KO_MbtN	0.043	-0.898
Trans05	1.589	0.061
macrophage_unactivated	1.525	0.139
IL1	-0.632	0.706
Rapamycin	0.829	-0.258
Tcell	0.189	-0.098
GMCSF	-0.684	-0.201
IFNab	0.913	0.112
IFNg	0.257	0.174
IFNg_GMCSF1	0.949	0.789
Rv1432_day32	0.404	-0.1
Rv1565c_day32	-1.989	-0.046
secA2_input	1.212	0.928
delta_Rv3594	-1.423	-0.441
delta_Rv3717	-0.25	-0.622
delta_Rv3811	-1.013	-0.669
delta_Rv0954	-0.174	0.557
PonA1	-0.635	-0.44
EccD1_KO	-1.145	-0.26
EspI_KO	-1.503	-0.385
PE35_KO	-1.727	-0.738
PPE68_KO	-1.619	-0.618
glycerol2	0.209	0.135
lignocerate	0.479	0.418
oleate	1.17	0.262
phosphatidylcholine	0.336	0.28
acetate	-0.444	-0.083
glucAc	0.622	0.051
Rv0950ko	0.286	1.604
Rv1096ko	2.117	1.514
Rv3684ko	2.492	1.837
delta_otsA_trehalose	0.139	1.079