TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0774c/-:

update plot	correlation	link to info on gene
Rv3365c/-	(cc=0.5138)	info on Rv3365c/-
Rv0354c/PPE7	(cc=0.4637)	info on Rv0354c/PPE7
Rv0811c/-	(cc=0.4382)	info on Rv0811c/-
Rv0194/-	(cc=0.4352)	info on Rv0194/-
Rv2882c/frr	(cc=0.4327)	info on Rv2882c/frr
Rv0232/-	(cc=0.4294)	info on Rv0232/-
Rv0276/-	(cc=0.4269)	info on Rv0276/-
Rv0701/rplC	(cc=0.4177)	info on Rv0701/rplC
Rv0033/acpA	(cc=0.4176)	info on Rv0033/acpA
Rv0301/vapC2	(cc=0.4167)	info on Rv0301/vapC2

Correlation of Rv0774c/- with Rv0194/-

Normalized LFCs for Rv0774c/-:
(description and provenance of datasets)

	Rv0774c/-	Rv0194/-
Fe_supp_jason_reseq	-0.415	-0.058
low_pH_jason_reseq	-0.621	-0.393
NO_jason_reseq	-0.129	0.037
B6_jason_reseq	-0.731	-0.047
MHCII_jason_reseq	-0.818	-0.046
Isoniazid02	-1.125	-0.858
Rifampicin4	0.902	0.203
Ethambutol3	-0.918	-0.409
Meropenem3	-0.926	-1.028
Vancomycin16	0.273	-0.464
Rv2680_day32	1.947	0.181
H37Rv_KO_MarP	-0.291	0.456
hypoxia_3wks	-0.311	0.056
hypoxia_6wks	-0.04	0.115
glycerol	-0.443	0.0
cholesterol	0.378	-0.104
AJ	-1.0	0.111
Bibs02	0.101	0.0
Bibs02c	0.252	0.035
BL6	0.576	0.133
BL6a	0.359	0.089
BXD01	0.054	-0.121
BXD010	0.035	0.049
BXD011	-0.193	0.049
BXD03	0.292	-0.036
BXD04	0.44	0.234
BXD05	-0.368	-0.11
BXD06	-0.118	0.076
BXD07	0.234	0.159
BXD08	0.16	0.043
BXD09	-0.19	-0.027
CAST	1.261	0.067
CCcont	-0.251	-0.01
DS01	0.816	-0.046
DS02	0.419	0.071
DS04	1.779	0.056
DS0c	-0.514	0.481
GP01	1.076	0.584
GP02	0.963	0.367
GP0c	0.501	-0.07
NOD	-0.164	0.164
NZO	-0.087	0.498
PWK	0.904	0.266
H37Rv_KO_CtpC	0.673	0.053
H37Rv_KO_CtpD	1.117	1.262
H37Rv_KO_Rv1272	-1.19	-0.274
H37Rv_KO_SugABC	-1.408	0.454
H37Rv_KO_MbtN	0.043	0.423
Trans05	1.589	0.303
macrophage_unactivated	1.525	-0.016
IL1	-0.632	-0.131
Rapamycin	0.829	-0.193
Tcell	0.189	-0.339
GMCSF	-0.684	0.063
IFNab	0.913	0.115
IFNg	0.257	0.051
IFNg_GMCSF1	0.949	0.148
Rv1432_day32	0.404	0.194
Rv1565c_day32	-1.989	-0.469
secA2_input	1.212	0.025
delta_Rv3594	-1.423	-0.304
delta_Rv3717	-0.25	-0.214
delta_Rv3811	-1.013	-0.173
delta_Rv0954	-0.174	-0.275
PonA1	-0.635	-0.54
EccD1_KO	-1.145	-0.168
EspI_KO	-1.503	-0.362
PE35_KO	-1.727	-0.519
PPE68_KO	-1.619	-0.518
glycerol2	0.209	0.61
lignocerate	0.479	0.496
oleate	1.17	0.564
phosphatidylcholine	0.336	0.335
acetate	-0.444	0.098
glucAc	0.622	-0.025
Rv0950ko	0.286	0.507
Rv1096ko	2.117	-0.341
Rv3684ko	2.492	0.0
delta_otsA_trehalose	0.139	-0.205