TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0774c/-:

update plot	correlation	link to info on gene
Rv3365c/-	(cc=0.5138)	info on Rv3365c/-
Rv0354c/PPE7	(cc=0.4637)	info on Rv0354c/PPE7
Rv0811c/-	(cc=0.4382)	info on Rv0811c/-
Rv0194/-	(cc=0.4352)	info on Rv0194/-
Rv2882c/frr	(cc=0.4327)	info on Rv2882c/frr
Rv0232/-	(cc=0.4294)	info on Rv0232/-
Rv0276/-	(cc=0.4269)	info on Rv0276/-
Rv0701/rplC	(cc=0.4177)	info on Rv0701/rplC
Rv0033/acpA	(cc=0.4176)	info on Rv0033/acpA
Rv0301/vapC2	(cc=0.4167)	info on Rv0301/vapC2

Correlation of Rv0774c/- with Rv0033/acpA

Normalized LFCs for Rv0774c/-:
(description and provenance of datasets)

	Rv0774c/-	Rv0033/acpA
Fe_supp_jason_reseq	-0.415	0.704
low_pH_jason_reseq	-0.621	-1.205
NO_jason_reseq	-0.129	-1.615
B6_jason_reseq	-0.731	-0.315
MHCII_jason_reseq	-0.818	-0.515
Isoniazid02	-1.125	-0.204
Rifampicin4	0.902	-1.021
Ethambutol3	-0.918	-0.602
Meropenem3	-0.926	1.161
Vancomycin16	0.273	-0.456
Rv2680_day32	1.947	-1.389
H37Rv_KO_MarP	-0.291	0.394
hypoxia_3wks	-0.311	1.499
hypoxia_6wks	-0.04	1.14
glycerol	-0.443	0.339
cholesterol	0.378	0.644
AJ	-1.0	1.055
Bibs02	0.101	1.15
Bibs02c	0.252	2.413
BL6	0.576	1.225
BL6a	0.359	0.798
BXD01	0.054	1.188
BXD010	0.035	1.775
BXD011	-0.193	0.887
BXD03	0.292	0.92
BXD04	0.44	1.559
BXD05	-0.368	-0.602
BXD06	-0.118	1.117
BXD07	0.234	1.222
BXD08	0.16	1.085
BXD09	-0.19	1.002
CAST	1.261	0.037
CCcont	-0.251	1.57
DS01	0.816	1.051
DS02	0.419	0.666
DS04	1.779	2.638
DS0c	-0.514	0.778
GP01	1.076	0.871
GP02	0.963	1.025
GP0c	0.501	1.651
NOD	-0.164	-0.225
NZO	-0.087	2.062
PWK	0.904	0.612
H37Rv_KO_CtpC	0.673	1.371
H37Rv_KO_CtpD	1.117	1.75
H37Rv_KO_Rv1272	-1.19	0.936
H37Rv_KO_SugABC	-1.408	-1.026
H37Rv_KO_MbtN	0.043	0.895
Trans05	1.589	0.685
macrophage_unactivated	1.525	1.6
IL1	-0.632	0.543
Rapamycin	0.829	1.967
Tcell	0.189	0.059
GMCSF	-0.684	1.191
IFNab	0.913	0.453
IFNg	0.257	-0.42
IFNg_GMCSF1	0.949	-0.072
Rv1432_day32	0.404	0.3
Rv1565c_day32	-1.989	-0.014
secA2_input	1.212	-0.344
delta_Rv3594	-1.423	-0.136
delta_Rv3717	-0.25	-0.473
delta_Rv3811	-1.013	0.336
delta_Rv0954	-0.174	-1.286
PonA1	-0.635	-0.95
EccD1_KO	-1.145	-0.454
EspI_KO	-1.503	-1.637
PE35_KO	-1.727	-0.799
PPE68_KO	-1.619	-0.928
glycerol2	0.209	0.724
lignocerate	0.479	0.426
oleate	1.17	0.926
phosphatidylcholine	0.336	0.758
acetate	-0.444	0.366
glucAc	0.622	0.108
Rv0950ko	0.286	1.824
Rv1096ko	2.117	2.31
Rv3684ko	2.492	1.886
delta_otsA_trehalose	0.139	0.975