TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0760c/-:

update plot	correlation	link to info on gene
Rv0932c/pstS2	(cc=0.5309)	info on Rv0932c/pstS2
Rv0130/htdZ	(cc=0.4933)	info on Rv0130/htdZ
Rv2884/-	(cc=0.444)	info on Rv2884/-
Rv1831/-	(cc=0.4256)	info on Rv1831/-
Rv2807/-	(cc=0.4173)	info on Rv2807/-
Rv1616/-	(cc=0.4159)	info on Rv1616/-
Rv3126c/-	(cc=0.4158)	info on Rv3126c/-
Rv2695/-	(cc=0.4158)	info on Rv2695/-
Rv1322/-	(cc=0.4131)	info on Rv1322/-
Rv3689/-	(cc=0.4118)	info on Rv3689/-

Correlation of Rv0760c/- with Rv3689/-

Normalized LFCs for Rv0760c/-:
(description and provenance of datasets)

	Rv0760c/-	Rv3689/-
Fe_supp_jason_reseq	-0.03	-0.388
low_pH_jason_reseq	-0.228	-1.681
NO_jason_reseq	-0.2	0.105
B6_jason_reseq	-0.084	0.499
MHCII_jason_reseq	-0.074	-0.62
Isoniazid02	0.058	-1.107
Rifampicin4	-0.625	0.495
Ethambutol3	-0.083	0.951
Meropenem3	-0.315	-0.364
Vancomycin16	-0.18	-0.058
Rv2680_day32	0.614	-0.811
H37Rv_KO_MarP	-0.58	-1.24
hypoxia_3wks	1.029	0.638
hypoxia_6wks	-0.378	0.739
glycerol	0.116	-0.295
cholesterol	-0.861	-0.2
AJ	0.341	0.576
Bibs02	0.172	-0.311
Bibs02c	0.377	-0.073
BL6	1.024	0.728
BL6a	1.002	0.844
BXD01	0.706	1.055
BXD010	1.072	0.8
BXD011	-0.31	0.852
BXD03	1.342	1.454
BXD04	0.341	1.548
BXD05	1.818	1.047
BXD06	0.306	0.962
BXD07	-0.055	1.026
BXD08	0.896	1.004
BXD09	0.711	0.486
CAST	1.885	1.677
CCcont	0.318	0.27
DS01	-0.245	-0.202
DS02	1.679	0.044
DS04	0.475	0.225
DS0c	1.123	-0.091
GP01	1.519	0.821
GP02	0.47	0.096
GP0c	0.0	0.85
NOD	0.877	0.957
NZO	-0.039	1.16
PWK	0.895	2.364
H37Rv_KO_CtpC	1.112	0.806
H37Rv_KO_CtpD	-0.512	0.981
H37Rv_KO_Rv1272	1.987	0.967
H37Rv_KO_SugABC	1.157	1.067
H37Rv_KO_MbtN	0.942	1.472
Trans05	1.943	0.496
macrophage_unactivated	1.222	0.079
IL1	0.89	-0.374
Rapamycin	0.485	-0.997
Tcell	1.121	0.508
GMCSF	0.544	0.132
IFNab	0.323	0.206
IFNg	1.563	0.722
IFNg_GMCSF1	-0.968	0.452
Rv1432_day32	1.915	1.172
Rv1565c_day32	-0.766	-0.482
secA2_input	-0.131	-0.488
delta_Rv3594	-0.187	-0.58
delta_Rv3717	0.693	-0.205
delta_Rv3811	-0.431	-0.21
delta_Rv0954	0.056	-0.979
PonA1	0.033	-0.099
EccD1_KO	2.368	0.122
EspI_KO	0.764	-0.217
PE35_KO	0.86	0.295
PPE68_KO	0.857	0.208
glycerol2	0.178	0.27
lignocerate	-0.416	-0.029
oleate	0.391	0.717
phosphatidylcholine	-0.154	-0.052
acetate	0.459	0.284
glucAc	-0.89	0.188
Rv0950ko	0.507	0.202
Rv1096ko	0.636	0.85
Rv3684ko	0.157	0.799
delta_otsA_trehalose	-0.876	-0.482