TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0760c/-:

update plot	correlation	link to info on gene
Rv0932c/pstS2	(cc=0.5309)	info on Rv0932c/pstS2
Rv0130/htdZ	(cc=0.4933)	info on Rv0130/htdZ
Rv2884/-	(cc=0.444)	info on Rv2884/-
Rv1831/-	(cc=0.4256)	info on Rv1831/-
Rv2807/-	(cc=0.4173)	info on Rv2807/-
Rv1616/-	(cc=0.4159)	info on Rv1616/-
Rv3126c/-	(cc=0.4158)	info on Rv3126c/-
Rv2695/-	(cc=0.4158)	info on Rv2695/-
Rv1322/-	(cc=0.4131)	info on Rv1322/-
Rv3689/-	(cc=0.4118)	info on Rv3689/-

Correlation of Rv0760c/- with Rv1322/-

Normalized LFCs for Rv0760c/-:
(description and provenance of datasets)

	Rv0760c/-	Rv1322/-
Fe_supp_jason_reseq	-0.03	-0.049
low_pH_jason_reseq	-0.228	1.201
NO_jason_reseq	-0.2	0.827
B6_jason_reseq	-0.084	-0.064
MHCII_jason_reseq	-0.074	-0.895
Isoniazid02	0.058	-1.106
Rifampicin4	-0.625	-0.333
Ethambutol3	-0.083	0.071
Meropenem3	-0.315	0.913
Vancomycin16	-0.18	0.751
Rv2680_day32	0.614	-1.054
H37Rv_KO_MarP	-0.58	-0.11
hypoxia_3wks	1.029	0.77
hypoxia_6wks	-0.378	0.365
glycerol	0.116	-1.3
cholesterol	-0.861	0.116
AJ	0.341	0.77
Bibs02	0.172	1.652
Bibs02c	0.377	0.787
BL6	1.024	1.305
BL6a	1.002	0.627
BXD01	0.706	0.471
BXD010	1.072	0.425
BXD011	-0.31	-0.33
BXD03	1.342	-0.388
BXD04	0.341	-0.053
BXD05	1.818	1.101
BXD06	0.306	0.597
BXD07	-0.055	-0.488
BXD08	0.896	1.778
BXD09	0.711	0.131
CAST	1.885	2.676
CCcont	0.318	-0.248
DS01	-0.245	0.436
DS02	1.679	1.679
DS04	0.475	0.156
DS0c	1.123	-0.256
GP01	1.519	1.34
GP02	0.47	1.875
GP0c	0.0	1.32
NOD	0.877	0.675
NZO	-0.039	0.9
PWK	0.895	1.421
H37Rv_KO_CtpC	1.112	2.814
H37Rv_KO_CtpD	-0.512	-1.258
H37Rv_KO_Rv1272	1.987	1.315
H37Rv_KO_SugABC	1.157	-0.704
H37Rv_KO_MbtN	0.942	-0.405
Trans05	1.943	1.981
macrophage_unactivated	1.222	-1.25
IL1	0.89	-0.175
Rapamycin	0.485	-0.773
Tcell	1.121	0.57
GMCSF	0.544	0.401
IFNab	0.323	-0.738
IFNg	1.563	0.422
IFNg_GMCSF1	-0.968	0.424
Rv1432_day32	1.915	0.859
Rv1565c_day32	-0.766	-0.618
secA2_input	-0.131	-0.759
delta_Rv3594	-0.187	-2.354
delta_Rv3717	0.693	-2.318
delta_Rv3811	-0.431	-1.679
delta_Rv0954	0.056	-1.553
PonA1	0.033	0.394
EccD1_KO	2.368	0.868
EspI_KO	0.764	0.208
PE35_KO	0.86	-0.099
PPE68_KO	0.857	0.208
glycerol2	0.178	-0.247
lignocerate	-0.416	-0.241
oleate	0.391	0.829
phosphatidylcholine	-0.154	0.573
acetate	0.459	0.063
glucAc	-0.89	-0.779
Rv0950ko	0.507	1.71
Rv1096ko	0.636	0.157
Rv3684ko	0.157	0.242
delta_otsA_trehalose	-0.876	-0.667