TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0760c/-:

update plot	correlation	link to info on gene
Rv0932c/pstS2	(cc=0.5309)	info on Rv0932c/pstS2
Rv0130/htdZ	(cc=0.4933)	info on Rv0130/htdZ
Rv2884/-	(cc=0.444)	info on Rv2884/-
Rv1831/-	(cc=0.4256)	info on Rv1831/-
Rv2807/-	(cc=0.4173)	info on Rv2807/-
Rv1616/-	(cc=0.4159)	info on Rv1616/-
Rv3126c/-	(cc=0.4158)	info on Rv3126c/-
Rv2695/-	(cc=0.4158)	info on Rv2695/-
Rv1322/-	(cc=0.4131)	info on Rv1322/-
Rv3689/-	(cc=0.4118)	info on Rv3689/-

Correlation of Rv0760c/- with Rv2884/-

Normalized LFCs for Rv0760c/-:
(description and provenance of datasets)

	Rv0760c/-	Rv2884/-
Fe_supp_jason_reseq	-0.03	-0.466
low_pH_jason_reseq	-0.228	0.294
NO_jason_reseq	-0.2	-1.483
B6_jason_reseq	-0.084	0.101
MHCII_jason_reseq	-0.074	0.356
Isoniazid02	0.058	0.796
Rifampicin4	-0.625	-0.717
Ethambutol3	-0.083	0.393
Meropenem3	-0.315	-0.113
Vancomycin16	-0.18	-0.515
Rv2680_day32	0.614	-0.151
H37Rv_KO_MarP	-0.58	-0.666
hypoxia_3wks	1.029	-0.319
hypoxia_6wks	-0.378	-0.094
glycerol	0.116	0.057
cholesterol	-0.861	-0.684
AJ	0.341	-0.682
Bibs02	0.172	0.229
Bibs02c	0.377	0.209
BL6	1.024	-0.859
BL6a	1.002	0.346
BXD01	0.706	0.248
BXD010	1.072	-0.531
BXD011	-0.31	0.359
BXD03	1.342	0.672
BXD04	0.341	-0.274
BXD05	1.818	-0.191
BXD06	0.306	-0.265
BXD07	-0.055	-0.407
BXD08	0.896	0.555
BXD09	0.711	0.375
CAST	1.885	0.169
CCcont	0.318	-0.043
DS01	-0.245	0.067
DS02	1.679	0.414
DS04	0.475	-0.523
DS0c	1.123	0.0
GP01	1.519	1.34
GP02	0.47	0.693
GP0c	0.0	0.639
NOD	0.877	0.532
NZO	-0.039	-0.178
PWK	0.895	0.279
H37Rv_KO_CtpC	1.112	-0.015
H37Rv_KO_CtpD	-0.512	-1.213
H37Rv_KO_Rv1272	1.987	2.348
H37Rv_KO_SugABC	1.157	0.107
H37Rv_KO_MbtN	0.942	1.712
Trans05	1.943	1.374
macrophage_unactivated	1.222	-0.363
IL1	0.89	0.0
Rapamycin	0.485	-0.353
Tcell	1.121	0.567
GMCSF	0.544	0.657
IFNab	0.323	0.254
IFNg	1.563	-0.885
IFNg_GMCSF1	-0.968	-0.157
Rv1432_day32	1.915	-0.222
Rv1565c_day32	-0.766	-0.828
secA2_input	-0.131	-0.538
delta_Rv3594	-0.187	0.089
delta_Rv3717	0.693	-0.24
delta_Rv3811	-0.431	-0.516
delta_Rv0954	0.056	-0.262
PonA1	0.033	-0.538
EccD1_KO	2.368	0.342
EspI_KO	0.764	0.684
PE35_KO	0.86	1.333
PPE68_KO	0.857	1.872
glycerol2	0.178	0.077
lignocerate	-0.416	-0.267
oleate	0.391	0.391
phosphatidylcholine	-0.154	0.464
acetate	0.459	-0.364
glucAc	-0.89	-0.944
Rv0950ko	0.507	-0.422
Rv1096ko	0.636	-0.685
Rv3684ko	0.157	-0.033
delta_otsA_trehalose	-0.876	-0.427