TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0760c/-:

update plot	correlation	link to info on gene
Rv0932c/pstS2	(cc=0.5309)	info on Rv0932c/pstS2
Rv0130/htdZ	(cc=0.4933)	info on Rv0130/htdZ
Rv2884/-	(cc=0.444)	info on Rv2884/-
Rv1831/-	(cc=0.4256)	info on Rv1831/-
Rv2807/-	(cc=0.4173)	info on Rv2807/-
Rv1616/-	(cc=0.4159)	info on Rv1616/-
Rv3126c/-	(cc=0.4158)	info on Rv3126c/-
Rv2695/-	(cc=0.4158)	info on Rv2695/-
Rv1322/-	(cc=0.4131)	info on Rv1322/-
Rv3689/-	(cc=0.4118)	info on Rv3689/-

Correlation of Rv0760c/- with Rv3126c/-

Normalized LFCs for Rv0760c/-:
(description and provenance of datasets)

	Rv0760c/-	Rv3126c/-
Fe_supp_jason_reseq	-0.03	-1.953
low_pH_jason_reseq	-0.228	-0.397
NO_jason_reseq	-0.2	-1.205
B6_jason_reseq	-0.084	-1.911
MHCII_jason_reseq	-0.074	-1.426
Isoniazid02	0.058	-0.506
Rifampicin4	-0.625	0.758
Ethambutol3	-0.083	0.179
Meropenem3	-0.315	0.0
Vancomycin16	-0.18	0.512
Rv2680_day32	0.614	-0.131
H37Rv_KO_MarP	-0.58	-0.207
hypoxia_3wks	1.029	1.017
hypoxia_6wks	-0.378	0.677
glycerol	0.116	-0.554
cholesterol	-0.861	-0.398
AJ	0.341	-0.637
Bibs02	0.172	-0.319
Bibs02c	0.377	-0.365
BL6	1.024	2.573
BL6a	1.002	3.655
BXD01	0.706	2.127
BXD010	1.072	2.796
BXD011	-0.31	1.711
BXD03	1.342	2.925
BXD04	0.341	0.992
BXD05	1.818	2.388
BXD06	0.306	3.202
BXD07	-0.055	2.751
BXD08	0.896	3.313
BXD09	0.711	3.562
CAST	1.885	2.518
CCcont	0.318	2.334
DS01	-0.245	-0.648
DS02	1.679	0.61
DS04	0.475	-0.533
DS0c	1.123	-0.596
GP01	1.519	-0.271
GP02	0.47	-0.228
GP0c	0.0	-0.357
NOD	0.877	3.705
NZO	-0.039	-0.548
PWK	0.895	-0.539
H37Rv_KO_CtpC	1.112	-0.446
H37Rv_KO_CtpD	-0.512	-0.221
H37Rv_KO_Rv1272	1.987	1.328
H37Rv_KO_SugABC	1.157	-0.272
H37Rv_KO_MbtN	0.942	-0.18
Trans05	1.943	-0.109
macrophage_unactivated	1.222	1.001
IL1	0.89	-0.664
Rapamycin	0.485	0.819
Tcell	1.121	0.736
GMCSF	0.544	0.399
IFNab	0.323	-0.151
IFNg	1.563	-0.27
IFNg_GMCSF1	-0.968	1.059
Rv1432_day32	1.915	0.0
Rv1565c_day32	-0.766	0.0
secA2_input	-0.131	-1.781
delta_Rv3594	-0.187	-3.114
delta_Rv3717	0.693	-0.629
delta_Rv3811	-0.431	-0.977
delta_Rv0954	0.056	0.83
PonA1	0.033	-0.127
EccD1_KO	2.368	3.762
EspI_KO	0.764	0.605
PE35_KO	0.86	1.479
PPE68_KO	0.857	2.259
glycerol2	0.178	0.029
lignocerate	-0.416	-0.739
oleate	0.391	1.014
phosphatidylcholine	-0.154	0.333
acetate	0.459	-0.224
glucAc	-0.89	-2.282
Rv0950ko	0.507	-0.347
Rv1096ko	0.636	-0.597
Rv3684ko	0.157	1.172
delta_otsA_trehalose	-0.876	0.0