TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0760c/-:

update plot	correlation	link to info on gene
Rv0932c/pstS2	(cc=0.5309)	info on Rv0932c/pstS2
Rv0130/htdZ	(cc=0.4933)	info on Rv0130/htdZ
Rv2884/-	(cc=0.444)	info on Rv2884/-
Rv1831/-	(cc=0.4256)	info on Rv1831/-
Rv2807/-	(cc=0.4173)	info on Rv2807/-
Rv1616/-	(cc=0.4159)	info on Rv1616/-
Rv3126c/-	(cc=0.4158)	info on Rv3126c/-
Rv2695/-	(cc=0.4158)	info on Rv2695/-
Rv1322/-	(cc=0.4131)	info on Rv1322/-
Rv3689/-	(cc=0.4118)	info on Rv3689/-

Correlation of Rv0760c/- with Rv2695/-

Normalized LFCs for Rv0760c/-:
(description and provenance of datasets)

	Rv0760c/-	Rv2695/-
Fe_supp_jason_reseq	-0.03	0.0
low_pH_jason_reseq	-0.228	-0.8
NO_jason_reseq	-0.2	0.711
B6_jason_reseq	-0.084	-0.11
MHCII_jason_reseq	-0.074	0.544
Isoniazid02	0.058	0.664
Rifampicin4	-0.625	0.799
Ethambutol3	-0.083	0.759
Meropenem3	-0.315	0.167
Vancomycin16	-0.18	0.074
Rv2680_day32	0.614	1.658
H37Rv_KO_MarP	-0.58	-0.137
hypoxia_3wks	1.029	0.0
hypoxia_6wks	-0.378	0.85
glycerol	0.116	-0.098
cholesterol	-0.861	0.328
AJ	0.341	1.126
Bibs02	0.172	1.22
Bibs02c	0.377	0.527
BL6	1.024	0.703
BL6a	1.002	0.743
BXD01	0.706	1.038
BXD010	1.072	0.948
BXD011	-0.31	0.722
BXD03	1.342	0.514
BXD04	0.341	0.342
BXD05	1.818	1.327
BXD06	0.306	0.224
BXD07	-0.055	0.771
BXD08	0.896	1.103
BXD09	0.711	0.479
CAST	1.885	0.053
CCcont	0.318	0.178
DS01	-0.245	1.935
DS02	1.679	1.531
DS04	0.475	2.09
DS0c	1.123	0.965
GP01	1.519	2.283
GP02	0.47	2.524
GP0c	0.0	2.06
NOD	0.877	-0.146
NZO	-0.039	0.704
PWK	0.895	0.432
H37Rv_KO_CtpC	1.112	1.098
H37Rv_KO_CtpD	-0.512	0.851
H37Rv_KO_Rv1272	1.987	1.466
H37Rv_KO_SugABC	1.157	1.415
H37Rv_KO_MbtN	0.942	1.95
Trans05	1.943	1.609
macrophage_unactivated	1.222	0.366
IL1	0.89	1.038
Rapamycin	0.485	1.04
Tcell	1.121	0.358
GMCSF	0.544	-0.071
IFNab	0.323	-0.039
IFNg	1.563	-0.861
IFNg_GMCSF1	-0.968	0.167
Rv1432_day32	1.915	2.315
Rv1565c_day32	-0.766	-0.531
secA2_input	-0.131	-0.495
delta_Rv3594	-0.187	-0.424
delta_Rv3717	0.693	-0.293
delta_Rv3811	-0.431	-0.958
delta_Rv0954	0.056	-0.603
PonA1	0.033	-1.173
EccD1_KO	2.368	0.681
EspI_KO	0.764	0.08
PE35_KO	0.86	0.379
PPE68_KO	0.857	0.397
glycerol2	0.178	-0.577
lignocerate	-0.416	-0.828
oleate	0.391	-0.478
phosphatidylcholine	-0.154	-2.76
acetate	0.459	-0.771
glucAc	-0.89	-0.837
Rv0950ko	0.507	0.802
Rv1096ko	0.636	0.365
Rv3684ko	0.157	0.652
delta_otsA_trehalose	-0.876	-1.39