TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0672/fadE8:

update plot	correlation	link to info on gene
Rv3688c/-	(cc=0.4544)	info on Rv3688c/-
Rv2390c/-	(cc=0.4518)	info on Rv2390c/-
Rv0104/-	(cc=0.4456)	info on Rv0104/-
Rv3406/-	(cc=0.435)	info on Rv3406/-
Rv0831c/-	(cc=0.4276)	info on Rv0831c/-
Rv3740c/-	(cc=0.426)	info on Rv3740c/-
Rv3742c/-	(cc=0.4194)	info on Rv3742c/-
Rv2675c/-	(cc=0.4165)	info on Rv2675c/-
Rv1413/-	(cc=0.4161)	info on Rv1413/-
Rv3323c/moaX	(cc=0.4145)	info on Rv3323c/moaX

Correlation of Rv0672/fadE8 with Rv3742c/-

Normalized LFCs for Rv0672/fadE8:
(description and provenance of datasets)

	Rv0672/fadE8	Rv3742c/-
Fe_supp_jason_reseq	-0.06	0.702
low_pH_jason_reseq	-0.512	-0.606
NO_jason_reseq	0.58	-0.879
B6_jason_reseq	-0.085	0.213
MHCII_jason_reseq	0.257	-0.14
Isoniazid02	-0.911	-2.023
Rifampicin4	0.33	-0.414
Ethambutol3	-0.091	-0.238
Meropenem3	-0.212	-0.773
Vancomycin16	-0.371	-1.061
Rv2680_day32	0.448	-0.87
H37Rv_KO_MarP	0.188	0.188
hypoxia_3wks	0.0	0.128
hypoxia_6wks	0.144	-0.484
glycerol	-0.847	-0.74
cholesterol	0.253	0.085
AJ	-0.413	-0.526
Bibs02	0.51	-0.158
Bibs02c	-0.417	-0.385
BL6	0.227	0.53
BL6a	0.017	0.436
BXD01	0.283	-0.144
BXD010	0.391	0.911
BXD011	0.397	0.708
BXD03	0.024	0.651
BXD04	1.103	-0.073
BXD05	0.0	0.482
BXD06	0.424	0.307
BXD07	0.591	0.467
BXD08	0.431	0.644
BXD09	0.5	0.295
CAST	0.334	0.115
CCcont	0.136	0.242
DS01	-0.021	0.051
DS02	0.348	0.262
DS04	0.462	1.092
DS0c	0.676	-0.049
GP01	0.18	1.204
GP02	1.699	0.907
GP0c	0.486	0.655
NOD	-0.161	-1.025
NZO	-0.377	-0.66
PWK	0.328	-0.051
H37Rv_KO_CtpC	-0.411	1.132
H37Rv_KO_CtpD	-0.687	1.341
H37Rv_KO_Rv1272	-0.357	1.592
H37Rv_KO_SugABC	1.214	1.254
H37Rv_KO_MbtN	1.119	0.419
Trans05	0.364	0.72
macrophage_unactivated	-0.268	-0.085
IL1	0.409	-0.113
Rapamycin	-0.064	-0.021
Tcell	-0.068	-0.283
GMCSF	-0.253	-0.269
IFNab	-0.357	-0.021
IFNg	0.369	-0.331
IFNg_GMCSF1	0.578	0.955
Rv1432_day32	0.771	-0.386
Rv1565c_day32	0.524	0.738
secA2_input	-0.409	-0.193
delta_Rv3594	0.462	-0.463
delta_Rv3717	0.206	0.141
delta_Rv3811	0.464	0.019
delta_Rv0954	-0.049	0.72
PonA1	0.111	0.904
EccD1_KO	-0.062	-0.457
EspI_KO	-0.228	-0.405
PE35_KO	-0.055	-0.3
PPE68_KO	0.122	-0.454
glycerol2	1.159	0.397
lignocerate	0.828	0.55
oleate	1.293	0.052
phosphatidylcholine	0.48	0.331
acetate	0.025	0.052
glucAc	0.063	0.26
Rv0950ko	0.675	0.742
Rv1096ko	1.074	0.6
Rv3684ko	0.986	0.586
delta_otsA_trehalose	1.295	3.512