TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0672/fadE8:

update plot	correlation	link to info on gene
Rv3688c/-	(cc=0.4544)	info on Rv3688c/-
Rv2390c/-	(cc=0.4518)	info on Rv2390c/-
Rv0104/-	(cc=0.4456)	info on Rv0104/-
Rv3406/-	(cc=0.435)	info on Rv3406/-
Rv0831c/-	(cc=0.4276)	info on Rv0831c/-
Rv3740c/-	(cc=0.426)	info on Rv3740c/-
Rv3742c/-	(cc=0.4194)	info on Rv3742c/-
Rv2675c/-	(cc=0.4165)	info on Rv2675c/-
Rv1413/-	(cc=0.4161)	info on Rv1413/-
Rv3323c/moaX	(cc=0.4145)	info on Rv3323c/moaX

Correlation of Rv0672/fadE8 with Rv3740c/-

Normalized LFCs for Rv0672/fadE8:
(description and provenance of datasets)

	Rv0672/fadE8	Rv3740c/-
Fe_supp_jason_reseq	-0.06	0.145
low_pH_jason_reseq	-0.512	-0.674
NO_jason_reseq	0.58	-0.06
B6_jason_reseq	-0.085	-0.578
MHCII_jason_reseq	0.257	-0.239
Isoniazid02	-0.911	-0.576
Rifampicin4	0.33	-0.219
Ethambutol3	-0.091	-0.366
Meropenem3	-0.212	-0.54
Vancomycin16	-0.371	-0.39
Rv2680_day32	0.448	0.536
H37Rv_KO_MarP	0.188	0.538
hypoxia_3wks	0.0	-0.199
hypoxia_6wks	0.144	-0.618
glycerol	-0.847	-0.057
cholesterol	0.253	-0.061
AJ	-0.413	-0.192
Bibs02	0.51	0.11
Bibs02c	-0.417	0.036
BL6	0.227	-0.146
BL6a	0.017	-0.293
BXD01	0.283	-0.229
BXD010	0.391	-0.38
BXD011	0.397	0.085
BXD03	0.024	-0.552
BXD04	1.103	-0.499
BXD05	0.0	0.439
BXD06	0.424	-0.115
BXD07	0.591	-0.114
BXD08	0.431	-0.105
BXD09	0.5	0.014
CAST	0.334	-0.964
CCcont	0.136	-0.14
DS01	-0.021	0.291
DS02	0.348	0.49
DS04	0.462	0.908
DS0c	0.676	0.465
GP01	0.18	0.547
GP02	1.699	1.436
GP0c	0.486	-0.316
NOD	-0.161	-0.626
NZO	-0.377	0.04
PWK	0.328	-0.443
H37Rv_KO_CtpC	-0.411	-0.417
H37Rv_KO_CtpD	-0.687	-0.162
H37Rv_KO_Rv1272	-0.357	0.491
H37Rv_KO_SugABC	1.214	0.25
H37Rv_KO_MbtN	1.119	0.212
Trans05	0.364	0.352
macrophage_unactivated	-0.268	-0.218
IL1	0.409	-0.466
Rapamycin	-0.064	-0.482
Tcell	-0.068	-0.743
GMCSF	-0.253	-0.158
IFNab	-0.357	0.121
IFNg	0.369	-0.147
IFNg_GMCSF1	0.578	0.167
Rv1432_day32	0.771	0.203
Rv1565c_day32	0.524	0.024
secA2_input	-0.409	0.124
delta_Rv3594	0.462	-0.404
delta_Rv3717	0.206	-0.339
delta_Rv3811	0.464	-0.013
delta_Rv0954	-0.049	0.417
PonA1	0.111	-0.215
EccD1_KO	-0.062	0.362
EspI_KO	-0.228	-0.391
PE35_KO	-0.055	-0.359
PPE68_KO	0.122	-0.381
glycerol2	1.159	0.384
lignocerate	0.828	0.1
oleate	1.293	0.544
phosphatidylcholine	0.48	0.197
acetate	0.025	-0.231
glucAc	0.063	-0.365
Rv0950ko	0.675	0.154
Rv1096ko	1.074	0.317
Rv3684ko	0.986	0.888
delta_otsA_trehalose	1.295	-0.356