TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0672/fadE8:

update plot	correlation	link to info on gene
Rv3688c/-	(cc=0.4544)	info on Rv3688c/-
Rv2390c/-	(cc=0.4518)	info on Rv2390c/-
Rv0104/-	(cc=0.4456)	info on Rv0104/-
Rv3406/-	(cc=0.435)	info on Rv3406/-
Rv0831c/-	(cc=0.4276)	info on Rv0831c/-
Rv3740c/-	(cc=0.426)	info on Rv3740c/-
Rv3742c/-	(cc=0.4194)	info on Rv3742c/-
Rv2675c/-	(cc=0.4165)	info on Rv2675c/-
Rv1413/-	(cc=0.4161)	info on Rv1413/-
Rv3323c/moaX	(cc=0.4145)	info on Rv3323c/moaX

Correlation of Rv0672/fadE8 with Rv2675c/-

Normalized LFCs for Rv0672/fadE8:
(description and provenance of datasets)

	Rv0672/fadE8	Rv2675c/-
Fe_supp_jason_reseq	-0.06	-0.175
low_pH_jason_reseq	-0.512	-1.365
NO_jason_reseq	0.58	-0.328
B6_jason_reseq	-0.085	0.019
MHCII_jason_reseq	0.257	0.626
Isoniazid02	-0.911	-1.043
Rifampicin4	0.33	-0.225
Ethambutol3	-0.091	-0.699
Meropenem3	-0.212	-1.433
Vancomycin16	-0.371	-1.082
Rv2680_day32	0.448	0.135
H37Rv_KO_MarP	0.188	0.024
hypoxia_3wks	0.0	0.171
hypoxia_6wks	0.144	1.038
glycerol	-0.847	0.443
cholesterol	0.253	-0.016
AJ	-0.413	-0.361
Bibs02	0.51	-0.029
Bibs02c	-0.417	0.023
BL6	0.227	0.213
BL6a	0.017	0.278
BXD01	0.283	0.092
BXD010	0.391	-0.175
BXD011	0.397	0.054
BXD03	0.024	-0.113
BXD04	1.103	0.284
BXD05	0.0	0.426
BXD06	0.424	0.275
BXD07	0.591	0.27
BXD08	0.431	0.052
BXD09	0.5	0.177
CAST	0.334	0.207
CCcont	0.136	0.067
DS01	-0.021	0.241
DS02	0.348	0.269
DS04	0.462	0.015
DS0c	0.676	0.168
GP01	0.18	-0.24
GP02	1.699	0.066
GP0c	0.486	-0.004
NOD	-0.161	0.397
NZO	-0.377	-0.237
PWK	0.328	-0.053
H37Rv_KO_CtpC	-0.411	-0.32
H37Rv_KO_CtpD	-0.687	-0.578
H37Rv_KO_Rv1272	-0.357	0.284
H37Rv_KO_SugABC	1.214	0.62
H37Rv_KO_MbtN	1.119	-0.47
Trans05	0.364	0.202
macrophage_unactivated	-0.268	-0.104
IL1	0.409	-0.098
Rapamycin	-0.064	-0.11
Tcell	-0.068	-0.117
GMCSF	-0.253	0.597
IFNab	-0.357	-0.091
IFNg	0.369	0.35
IFNg_GMCSF1	0.578	0.277
Rv1432_day32	0.771	0.108
Rv1565c_day32	0.524	-0.032
secA2_input	-0.409	-0.177
delta_Rv3594	0.462	0.251
delta_Rv3717	0.206	-0.103
delta_Rv3811	0.464	-0.406
delta_Rv0954	-0.049	-0.337
PonA1	0.111	0.121
EccD1_KO	-0.062	0.266
EspI_KO	-0.228	0.528
PE35_KO	-0.055	0.163
PPE68_KO	0.122	0.032
glycerol2	1.159	0.657
lignocerate	0.828	0.979
oleate	1.293	0.464
phosphatidylcholine	0.48	0.819
acetate	0.025	0.233
glucAc	0.063	0.485
Rv0950ko	0.675	0.887
Rv1096ko	1.074	0.124
Rv3684ko	0.986	0.737
delta_otsA_trehalose	1.295	0.353