TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0672/fadE8:

update plot	correlation	link to info on gene
Rv3688c/-	(cc=0.4544)	info on Rv3688c/-
Rv2390c/-	(cc=0.4518)	info on Rv2390c/-
Rv0104/-	(cc=0.4456)	info on Rv0104/-
Rv3406/-	(cc=0.435)	info on Rv3406/-
Rv0831c/-	(cc=0.4276)	info on Rv0831c/-
Rv3740c/-	(cc=0.426)	info on Rv3740c/-
Rv3742c/-	(cc=0.4194)	info on Rv3742c/-
Rv2675c/-	(cc=0.4165)	info on Rv2675c/-
Rv1413/-	(cc=0.4161)	info on Rv1413/-
Rv3323c/moaX	(cc=0.4145)	info on Rv3323c/moaX

Correlation of Rv0672/fadE8 with Rv3323c/moaX

Normalized LFCs for Rv0672/fadE8:
(description and provenance of datasets)

	Rv0672/fadE8	Rv3323c/moaX
Fe_supp_jason_reseq	-0.06	-0.489
low_pH_jason_reseq	-0.512	-0.979
NO_jason_reseq	0.58	0.108
B6_jason_reseq	-0.085	-0.72
MHCII_jason_reseq	0.257	-0.19
Isoniazid02	-0.911	-1.218
Rifampicin4	0.33	-0.241
Ethambutol3	-0.091	-1.009
Meropenem3	-0.212	-1.305
Vancomycin16	-0.371	-0.682
Rv2680_day32	0.448	-0.133
H37Rv_KO_MarP	0.188	0.236
hypoxia_3wks	0.0	-0.14
hypoxia_6wks	0.144	-0.449
glycerol	-0.847	0.505
cholesterol	0.253	0.13
AJ	-0.413	0.124
Bibs02	0.51	0.011
Bibs02c	-0.417	-0.491
BL6	0.227	0.344
BL6a	0.017	0.055
BXD01	0.283	0.091
BXD010	0.391	-0.511
BXD011	0.397	0.114
BXD03	0.024	-0.023
BXD04	1.103	-0.369
BXD05	0.0	-0.085
BXD06	0.424	0.072
BXD07	0.591	-0.031
BXD08	0.431	-0.231
BXD09	0.5	0.023
CAST	0.334	0.013
CCcont	0.136	0.3
DS01	-0.021	-0.758
DS02	0.348	0.047
DS04	0.462	0.468
DS0c	0.676	0.239
GP01	0.18	0.507
GP02	1.699	-0.353
GP0c	0.486	0.632
NOD	-0.161	0.542
NZO	-0.377	-0.296
PWK	0.328	0.59
H37Rv_KO_CtpC	-0.411	0.053
H37Rv_KO_CtpD	-0.687	-0.043
H37Rv_KO_Rv1272	-0.357	0.039
H37Rv_KO_SugABC	1.214	0.114
H37Rv_KO_MbtN	1.119	0.903
Trans05	0.364	-0.43
macrophage_unactivated	-0.268	-0.331
IL1	0.409	0.314
Rapamycin	-0.064	0.371
Tcell	-0.068	0.319
GMCSF	-0.253	0.217
IFNab	-0.357	-0.079
IFNg	0.369	-0.428
IFNg_GMCSF1	0.578	1.037
Rv1432_day32	0.771	0.716
Rv1565c_day32	0.524	0.956
secA2_input	-0.409	-0.661
delta_Rv3594	0.462	0.182
delta_Rv3717	0.206	-0.076
delta_Rv3811	0.464	-0.01
delta_Rv0954	-0.049	0.009
PonA1	0.111	0.492
EccD1_KO	-0.062	-0.779
EspI_KO	-0.228	-0.074
PE35_KO	-0.055	-0.23
PPE68_KO	0.122	-0.387
glycerol2	1.159	0.928
lignocerate	0.828	1.346
oleate	1.293	0.313
phosphatidylcholine	0.48	1.095
acetate	0.025	0.454
glucAc	0.063	0.473
Rv0950ko	0.675	-0.311
Rv1096ko	1.074	0.492
Rv3684ko	0.986	0.151
delta_otsA_trehalose	1.295	0.364