TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0672/fadE8:

update plot	correlation	link to info on gene
Rv3688c/-	(cc=0.4544)	info on Rv3688c/-
Rv2390c/-	(cc=0.4518)	info on Rv2390c/-
Rv0104/-	(cc=0.4456)	info on Rv0104/-
Rv3406/-	(cc=0.435)	info on Rv3406/-
Rv0831c/-	(cc=0.4276)	info on Rv0831c/-
Rv3740c/-	(cc=0.426)	info on Rv3740c/-
Rv3742c/-	(cc=0.4194)	info on Rv3742c/-
Rv2675c/-	(cc=0.4165)	info on Rv2675c/-
Rv1413/-	(cc=0.4161)	info on Rv1413/-
Rv3323c/moaX	(cc=0.4145)	info on Rv3323c/moaX

Correlation of Rv0672/fadE8 with Rv3688c/-

Normalized LFCs for Rv0672/fadE8:
(description and provenance of datasets)

	Rv0672/fadE8	Rv3688c/-
Fe_supp_jason_reseq	-0.06	-0.737
low_pH_jason_reseq	-0.512	0.5
NO_jason_reseq	0.58	0.21
B6_jason_reseq	-0.085	-0.529
MHCII_jason_reseq	0.257	0.319
Isoniazid02	-0.911	-0.952
Rifampicin4	0.33	-0.439
Ethambutol3	-0.091	-0.725
Meropenem3	-0.212	-0.383
Vancomycin16	-0.371	-0.862
Rv2680_day32	0.448	0.57
H37Rv_KO_MarP	0.188	0.233
hypoxia_3wks	0.0	0.941
hypoxia_6wks	0.144	0.662
glycerol	-0.847	-1.868
cholesterol	0.253	-0.148
AJ	-0.413	0.062
Bibs02	0.51	-0.011
Bibs02c	-0.417	0.0
BL6	0.227	0.439
BL6a	0.017	0.323
BXD01	0.283	-0.596
BXD010	0.391	0.178
BXD011	0.397	-0.205
BXD03	0.024	0.358
BXD04	1.103	0.192
BXD05	0.0	0.602
BXD06	0.424	0.629
BXD07	0.591	0.204
BXD08	0.431	0.455
BXD09	0.5	0.25
CAST	0.334	-0.057
CCcont	0.136	0.036
DS01	-0.021	-0.125
DS02	0.348	-0.55
DS04	0.462	-0.264
DS0c	0.676	0.668
GP01	0.18	-0.072
GP02	1.699	0.937
GP0c	0.486	-0.261
NOD	-0.161	-0.731
NZO	-0.377	0.09
PWK	0.328	0.578
H37Rv_KO_CtpC	-0.411	0.068
H37Rv_KO_CtpD	-0.687	-0.092
H37Rv_KO_Rv1272	-0.357	-0.197
H37Rv_KO_SugABC	1.214	1.124
H37Rv_KO_MbtN	1.119	0.108
Trans05	0.364	0.402
macrophage_unactivated	-0.268	0.038
IL1	0.409	-0.036
Rapamycin	-0.064	-0.338
Tcell	-0.068	0.062
GMCSF	-0.253	0.401
IFNab	-0.357	-0.181
IFNg	0.369	0.061
IFNg_GMCSF1	0.578	0.443
Rv1432_day32	0.771	-0.694
Rv1565c_day32	0.524	-1.243
secA2_input	-0.409	-0.016
delta_Rv3594	0.462	-0.505
delta_Rv3717	0.206	-0.842
delta_Rv3811	0.464	-0.44
delta_Rv0954	-0.049	-0.37
PonA1	0.111	0.651
EccD1_KO	-0.062	-0.125
EspI_KO	-0.228	-0.268
PE35_KO	-0.055	-0.98
PPE68_KO	0.122	-1.075
glycerol2	1.159	0.841
lignocerate	0.828	0.784
oleate	1.293	0.564
phosphatidylcholine	0.48	1.006
acetate	0.025	0.231
glucAc	0.063	0.359
Rv0950ko	0.675	0.305
Rv1096ko	1.074	-0.112
Rv3684ko	0.986	0.046
delta_otsA_trehalose	1.295	1.278