TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0581/vapB26:

update plot	correlation	link to info on gene
Rv1773c/-	(cc=0.5168)	info on Rv1773c/-
Rv2978c/-	(cc=0.4892)	info on Rv2978c/-
Rv0427c/xthA	(cc=0.4738)	info on Rv0427c/xthA
Rv2911/dacB2	(cc=0.4706)	info on Rv2911/dacB2
Rv3387/-	(cc=0.4672)	info on Rv3387/-
Rv0865/mog	(cc=0.4666)	info on Rv0865/mog
Rv2537c/aroD	(cc=0.4615)	info on Rv2537c/aroD
Rv0817c/-	(cc=0.4532)	info on Rv0817c/-
Rv2484c/-	(cc=0.4525)	info on Rv2484c/-
Rv2250A/-	(cc=0.4446)	info on Rv2250A/-

Correlation of Rv0581/vapB26 with Rv2978c/-

Normalized LFCs for Rv0581/vapB26:
(description and provenance of datasets)

	Rv0581/vapB26	Rv2978c/-
Fe_supp_jason_reseq	-1.017	-0.052
low_pH_jason_reseq	-1.952	-0.261
NO_jason_reseq	0.344	-0.221
B6_jason_reseq	-1.021	-1.303
MHCII_jason_reseq	-1.845	-1.184
Isoniazid02	0.457	0.611
Rifampicin4	0.907	0.753
Ethambutol3	0.716	1.126
Meropenem3	0.643	0.223
Vancomycin16	0.889	-0.146
Rv2680_day32	1.836	-0.586
H37Rv_KO_MarP	0.025	0.179
hypoxia_3wks	0.75	0.211
hypoxia_6wks	1.084	0.762
glycerol	-1.068	0.0
cholesterol	-0.322	0.526
AJ	-0.034	0.605
Bibs02	-2.073	-0.49
Bibs02c	1.05	0.377
BL6	-0.603	0.505
BL6a	1.319	0.517
BXD01	-0.306	0.473
BXD010	-0.339	0.334
BXD011	-0.239	0.445
BXD03	0.92	1.353
BXD04	-0.275	0.341
BXD05	-0.39	-0.054
BXD06	-0.438	0.263
BXD07	0.645	1.436
BXD08	0.217	0.367
BXD09	-0.313	0.491
CAST	0.28	0.377
CCcont	-0.51	0.478
DS01	0.142	0.387
DS02	-0.161	-0.944
DS04	1.019	-1.154
DS0c	-1.777	-0.696
GP01	-0.433	0.257
GP02	-1.32	0.627
GP0c	0.622	0.169
NOD	-1.084	0.0
NZO	0.267	-0.806
PWK	-0.176	0.418
H37Rv_KO_CtpC	-0.232	0.32
H37Rv_KO_CtpD	0.395	0.786
H37Rv_KO_Rv1272	-0.538	-0.086
H37Rv_KO_SugABC	1.218	1.188
H37Rv_KO_MbtN	-1.085	-0.809
Trans05	0.031	0.38
macrophage_unactivated	-0.518	0.922
IL1	0.786	0.234
Rapamycin	-0.282	-0.7
Tcell	-0.639	-0.619
GMCSF	-0.283	0.0
IFNab	-0.1	-0.2
IFNg	-0.553	-0.609
IFNg_GMCSF1	0.229	0.342
Rv1432_day32	-0.541	0.541
Rv1565c_day32	-0.373	-3.101
secA2_input	0.374	0.095
delta_Rv3594	0.395	1.892
delta_Rv3717	-0.068	0.165
delta_Rv3811	0.355	0.617
delta_Rv0954	0.712	1.336
PonA1	0.268	1.051
EccD1_KO	1.45	2.601
EspI_KO	0.613	2.524
PE35_KO	1.87	2.018
PPE68_KO	1.779	2.323
glycerol2	-0.413	-0.112
lignocerate	-0.879	-0.51
oleate	0.512	0.159
phosphatidylcholine	-0.273	0.0
acetate	-1.355	-1.358
glucAc	-1.912	-1.16
Rv0950ko	0.847	0.0
Rv1096ko	1.098	0.76
Rv3684ko	1.801	0.219
delta_otsA_trehalose	1.676	-0.659