TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0581/vapB26:

update plot	correlation	link to info on gene
Rv1773c/-	(cc=0.5168)	info on Rv1773c/-
Rv2978c/-	(cc=0.4892)	info on Rv2978c/-
Rv0427c/xthA	(cc=0.4738)	info on Rv0427c/xthA
Rv2911/dacB2	(cc=0.4706)	info on Rv2911/dacB2
Rv3387/-	(cc=0.4672)	info on Rv3387/-
Rv0865/mog	(cc=0.4666)	info on Rv0865/mog
Rv2537c/aroD	(cc=0.4615)	info on Rv2537c/aroD
Rv0817c/-	(cc=0.4532)	info on Rv0817c/-
Rv2484c/-	(cc=0.4525)	info on Rv2484c/-
Rv2250A/-	(cc=0.4446)	info on Rv2250A/-

Correlation of Rv0581/vapB26 with Rv2911/dacB2

Normalized LFCs for Rv0581/vapB26:
(description and provenance of datasets)

	Rv0581/vapB26	Rv2911/dacB2
Fe_supp_jason_reseq	-1.017	0.406
low_pH_jason_reseq	-1.952	-1.26
NO_jason_reseq	0.344	0.092
B6_jason_reseq	-1.021	-0.193
MHCII_jason_reseq	-1.845	-0.264
Isoniazid02	0.457	0.345
Rifampicin4	0.907	0.041
Ethambutol3	0.716	0.045
Meropenem3	0.643	-0.319
Vancomycin16	0.889	1.849
Rv2680_day32	1.836	0.404
H37Rv_KO_MarP	0.025	0.08
hypoxia_3wks	0.75	0.821
hypoxia_6wks	1.084	1.054
glycerol	-1.068	0.774
cholesterol	-0.322	0.0
AJ	-0.034	-0.318
Bibs02	-2.073	0.599
Bibs02c	1.05	0.831
BL6	-0.603	0.53
BL6a	1.319	0.773
BXD01	-0.306	-0.039
BXD010	-0.339	0.989
BXD011	-0.239	0.667
BXD03	0.92	-0.026
BXD04	-0.275	0.036
BXD05	-0.39	1.039
BXD06	-0.438	0.274
BXD07	0.645	0.675
BXD08	0.217	0.681
BXD09	-0.313	0.132
CAST	0.28	-0.504
CCcont	-0.51	0.672
DS01	0.142	0.922
DS02	-0.161	0.712
DS04	1.019	0.506
DS0c	-1.777	-0.156
GP01	-0.433	0.988
GP02	-1.32	-0.278
GP0c	0.622	-0.163
NOD	-1.084	-0.332
NZO	0.267	-0.436
PWK	-0.176	-0.551
H37Rv_KO_CtpC	-0.232	0.772
H37Rv_KO_CtpD	0.395	0.562
H37Rv_KO_Rv1272	-0.538	-0.699
H37Rv_KO_SugABC	1.218	1.362
H37Rv_KO_MbtN	-1.085	0.178
Trans05	0.031	0.05
macrophage_unactivated	-0.518	-0.11
IL1	0.786	0.777
Rapamycin	-0.282	0.552
Tcell	-0.639	-0.352
GMCSF	-0.283	0.201
IFNab	-0.1	0.426
IFNg	-0.553	0.313
IFNg_GMCSF1	0.229	1.276
Rv1432_day32	-0.541	0.413
Rv1565c_day32	-0.373	0.253
secA2_input	0.374	0.825
delta_Rv3594	0.395	0.405
delta_Rv3717	-0.068	0.503
delta_Rv3811	0.355	0.302
delta_Rv0954	0.712	0.302
PonA1	0.268	-0.306
EccD1_KO	1.45	0.895
EspI_KO	0.613	0.645
PE35_KO	1.87	1.26
PPE68_KO	1.779	1.251
glycerol2	-0.413	0.283
lignocerate	-0.879	0.339
oleate	0.512	0.071
phosphatidylcholine	-0.273	0.204
acetate	-1.355	0.145
glucAc	-1.912	0.471
Rv0950ko	0.847	0.775
Rv1096ko	1.098	0.995
Rv3684ko	1.801	1.081
delta_otsA_trehalose	1.676	0.942