TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0530/-:

update plot	correlation	link to info on gene
Rv1057/-	(cc=0.5674)	info on Rv1057/-
Rv0536/galE3	(cc=0.5137)	info on Rv0536/galE3
Rv2402/-	(cc=0.5029)	info on Rv2402/-
Rv0493c/-	(cc=0.496)	info on Rv0493c/-
Rv0113/gmhA	(cc=0.4933)	info on Rv0113/gmhA
Rv2748c/ftsK	(cc=0.4922)	info on Rv2748c/ftsK
Rv3294c/-	(cc=0.4876)	info on Rv3294c/-
Rv3786c/-	(cc=0.4871)	info on Rv3786c/-
Rv0134/ephF	(cc=0.4818)	info on Rv0134/ephF
Rv0442c/PPE10	(cc=0.4707)	info on Rv0442c/PPE10

Correlation of Rv0530/- with Rv2748c/ftsK

Normalized LFCs for Rv0530/-:
(description and provenance of datasets)

	Rv0530/-	Rv2748c/ftsK
Fe_supp_jason_reseq	-0.276	0.878
low_pH_jason_reseq	-0.321	-0.303
NO_jason_reseq	0.236	-1.016
B6_jason_reseq	0.625	0.74
MHCII_jason_reseq	0.96	1.731
Isoniazid02	0.292	0.097
Rifampicin4	-0.222	-0.19
Ethambutol3	0.582	0.159
Meropenem3	0.265	0.157
Vancomycin16	-0.838	1.101
Rv2680_day32	-0.954	-1.231
H37Rv_KO_MarP	0.12	0.0
hypoxia_3wks	-0.57	-0.502
hypoxia_6wks	-0.23	-0.263
glycerol	-0.044	0.0
cholesterol	-0.614	0.149
AJ	0.309	-0.173
Bibs02	0.351	0.065
Bibs02c	0.333	-0.506
BL6	-0.4	0.129
BL6a	0.042	0.07
BXD01	-0.154	0.794
BXD010	-0.646	-0.975
BXD011	-0.259	-0.308
BXD03	-0.672	0.182
BXD04	0.031	-0.357
BXD05	-0.544	-0.389
BXD06	-0.618	-0.049
BXD07	-0.137	0.9
BXD08	-0.277	-0.322
BXD09	-0.568	-0.278
CAST	0.864	0.0
CCcont	-0.12	0.0
DS01	1.025	0.914
DS02	-0.154	1.098
DS04	0.309	0.135
DS0c	0.787	1.367
GP01	0.37	-0.195
GP02	1.026	2.351
GP0c	0.212	0.09
NOD	0.029	-0.257
NZO	0.026	-0.309
PWK	0.742	0.136
H37Rv_KO_CtpC	-0.435	-1.808
H37Rv_KO_CtpD	0.327	0.0
H37Rv_KO_Rv1272	-1.102	-0.105
H37Rv_KO_SugABC	0.252	1.89
H37Rv_KO_MbtN	0.125	-0.785
Trans05	-0.813	-0.995
macrophage_unactivated	-0.331	0.398
IL1	0.208	0.715
Rapamycin	0.675	0.0
Tcell	-0.469	1.134
GMCSF	0.364	0.919
IFNab	-0.46	0.193
IFNg	-0.059	0.337
IFNg_GMCSF1	1.345	1.254
Rv1432_day32	0.849	0.0
Rv1565c_day32	-0.518	0.0
secA2_input	0.333	2.171
delta_Rv3594	-0.393	-0.802
delta_Rv3717	0.345	0.291
delta_Rv3811	-0.256	-0.779
delta_Rv0954	0.224	1.485
PonA1	0.391	-0.826
EccD1_KO	-0.444	-1.246
EspI_KO	-0.536	-0.328
PE35_KO	-0.099	-0.898
PPE68_KO	-0.55	-1.213
glycerol2	0.015	0.68
lignocerate	0.961	1.218
oleate	-0.472	-0.829
phosphatidylcholine	0.353	0.679
acetate	0.251	1.32
glucAc	0.367	1.176
Rv0950ko	0.244	0.874
Rv1096ko	0.29	0.458
Rv3684ko	0.39	1.359
delta_otsA_trehalose	0.888	0.232