TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv3638/-:

update plot	correlation	link to info on gene
Rv1989c/-	(cc=0.5864)	info on Rv1989c/-
Rv1374c/-	(cc=0.5662)	info on Rv1374c/-
Rv0849/-	(cc=0.55)	info on Rv0849/-
Rv1843c/guaB1	(cc=0.5423)	info on Rv1843c/guaB1
Rv2081c/-	(cc=0.5422)	info on Rv2081c/-
Rv1735c/-	(cc=0.5413)	info on Rv1735c/-
Rv0233/nrdB	(cc=0.5381)	info on Rv0233/nrdB
Rv1734c/-	(cc=0.5265)	info on Rv1734c/-
Rv0764c/cyp51	(cc=0.524)	info on Rv0764c/cyp51
Rv0846c/-	(cc=0.5185)	info on Rv0846c/-

Correlation of Rv3638/- with Rv1374c/-

Normalized LFCs for Rv3638/-:
(description and provenance of datasets)

	Rv3638/-	Rv1374c/-
Fe_supp_jason_reseq	0.081	-0.425
low_pH_jason_reseq	-0.144	-0.266
NO_jason_reseq	-0.139	-0.139
B6_jason_reseq	0.405	0.087
MHCII_jason_reseq	0.936	0.298
Isoniazid02	-0.124	0.813
Rifampicin4	-0.585	-0.16
Ethambutol3	-0.28	0.135
Meropenem3	-0.087	1.358
Vancomycin16	-0.096	0.117
Rv2680_day32	1.23	1.015
H37Rv_KO_MarP	0.8	0.34
hypoxia_3wks	-0.04	-0.486
hypoxia_6wks	0.297	-0.564
glycerol	-3.169	-1.842
cholesterol	-1.042	-1.07
AJ	0.037	-0.007
Bibs02	0.115	-0.06
Bibs02c	0.045	0.755
BL6	-1.463	-1.115
BL6a	-0.251	0.26
BXD01	-0.507	-0.56
BXD010	-1.283	-0.171
BXD011	-0.76	-0.336
BXD03	-0.637	-0.764
BXD04	0.181	-0.232
BXD05	-0.669	-0.816
BXD06	-0.399	-0.742
BXD07	-0.507	-0.284
BXD08	-0.72	-0.758
BXD09	-0.514	-0.269
CAST	-0.377	0.337
CCcont	-1.698	-0.859
DS01	0.243	0.021
DS02	0.339	0.228
DS04	0.55	0.136
DS0c	0.192	0.228
GP01	0.797	0.289
GP02	-0.644	-0.081
GP0c	0.062	-0.581
NOD	0.153	0.662
NZO	0.374	-0.564
PWK	-0.121	-0.51
H37Rv_KO_CtpC	-0.632	-0.67
H37Rv_KO_CtpD	0.04	0.691
H37Rv_KO_Rv1272	-0.187	-0.029
H37Rv_KO_SugABC	0.418	-0.697
H37Rv_KO_MbtN	0.044	-0.065
Trans05	-0.335	-0.354
macrophage_unactivated	-1.297	-0.155
IL1	-1.219	-0.492
Rapamycin	-1.016	-0.746
Tcell	-1.131	-0.14
GMCSF	-1.127	-0.66
IFNab	-1.001	-0.302
IFNg	-0.804	-0.216
IFNg_GMCSF1	-0.446	-0.233
Rv1432_day32	-0.789	0.329
Rv1565c_day32	1.17	0.246
secA2_input	-0.778	-1.343
delta_Rv3594	-0.014	-0.571
delta_Rv3717	-0.648	-0.359
delta_Rv3811	-0.581	-0.346
delta_Rv0954	0.35	-0.182
PonA1	0.178	-0.149
EccD1_KO	-0.362	-0.053
EspI_KO	-0.371	-0.123
PE35_KO	0.076	-0.047
PPE68_KO	0.432	0.083
glycerol2	0.015	-0.102
lignocerate	-0.627	0.156
oleate	0.092	0.162
phosphatidylcholine	0.207	0.169
acetate	-0.559	0.19
glucAc	-0.881	-0.219
Rv0950ko	-0.054	0.0
Rv1096ko	0.443	-0.896
Rv3684ko	-0.308	-0.144
delta_otsA_trehalose	0.021	-0.246