TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv3441c/mrsA:

update plot	correlation	link to info on gene
Rv0409/ackA	(cc=0.4518)	info on Rv0409/ackA
Rv1791/PE19	(cc=0.4206)	info on Rv1791/PE19
Rv2758c/vapB21	(cc=0.4201)	info on Rv2758c/vapB21
Rv2311/-	(cc=0.411)	info on Rv2311/-
Rv0736/rslA	(cc=0.3994)	info on Rv0736/rslA
Rv0062/celA1	(cc=0.3989)	info on Rv0062/celA1
Rv3780/-	(cc=0.3982)	info on Rv3780/-
Rv0863/-	(cc=0.3961)	info on Rv0863/-
Rv1112/-	(cc=0.3942)	info on Rv1112/-
Rv0418/lpqL	(cc=0.3899)	info on Rv0418/lpqL

Correlation of Rv3441c/mrsA with Rv1112/-

Normalized LFCs for Rv3441c/mrsA:
(description and provenance of datasets)

	Rv3441c/mrsA	Rv1112/-
Fe_supp_jason_reseq	0.474	1.901
low_pH_jason_reseq	-0.634	-1.571
NO_jason_reseq	-0.302	0.315
B6_jason_reseq	-0.421	-0.913
MHCII_jason_reseq	-0.37	0.0
Isoniazid02	0.351	3.87
Rifampicin4	0.341	0.712
Ethambutol3	0.293	1.414
Meropenem3	1.95	0.426
Vancomycin16	0.334	1.602
Rv2680_day32	0.0	0.109
H37Rv_KO_MarP	1.618	2.428
hypoxia_3wks	-0.55	-2.68
hypoxia_6wks	-0.288	-2.533
glycerol	0.385	2.487
cholesterol	0.0	1.62
AJ	0.0	1.78
Bibs02	1.123	0.0
Bibs02c	0.0	0.0
BL6	0.0	1.574
BL6a	0.0	1.964
BXD01	0.358	1.496
BXD010	0.244	1.739
BXD011	0.127	0.612
BXD03	0.0	1.146
BXD04	0.124	1.588
BXD05	0.0	1.241
BXD06	0.133	2.098
BXD07	0.138	0.809
BXD08	0.0	1.227
BXD09	0.0	2.005
CAST	0.0	1.458
CCcont	1.55	4.277
DS01	0.0	0.551
DS02	0.414	0.35
DS04	0.37	1.32
DS0c	0.0	0.652
GP01	0.0	0.36
GP02	0.0	-0.159
GP0c	0.0	-0.248
NOD	0.0	2.071
NZO	0.0	1.357
PWK	0.0	0.715
H37Rv_KO_CtpC	0.162	0.0
H37Rv_KO_CtpD	0.0	1.689
H37Rv_KO_Rv1272	0.0	0.753
H37Rv_KO_SugABC	0.0	1.666
H37Rv_KO_MbtN	0.0	1.959
Trans05	0.0	0.628
macrophage_unactivated	0.436	0.571
IL1	0.0	-1.326
Rapamycin	0.0	-0.307
Tcell	0.0	0.303
GMCSF	0.0	-0.85
IFNab	0.0	0.795
IFNg	0.0	-1.563
IFNg_GMCSF1	0.0	-0.647
Rv1432_day32	0.0	1.155
Rv1565c_day32	0.0	-0.256
secA2_input	0.197	-0.676
delta_Rv3594	0.895	4.577
delta_Rv3717	-0.331	4.406
delta_Rv3811	-0.391	3.248
delta_Rv0954	-0.34	0.969
PonA1	-0.304	-0.245
EccD1_KO	-0.378	-1.542
EspI_KO	-0.687	-1.879
PE35_KO	-1.105	-0.548
PPE68_KO	0.0	-0.902
glycerol2	0.0	0.395
lignocerate	0.32	-0.764
oleate	0.0	-0.588
phosphatidylcholine	0.193	-1.751
acetate	0.437	1.536
glucAc	0.501	2.08
Rv0950ko	0.0	0.862
Rv1096ko	0.905	0.398
Rv3684ko	0.0	0.829
delta_otsA_trehalose	-0.654	0.4