TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv3441c/mrsA:

update plot	correlation	link to info on gene
Rv0409/ackA	(cc=0.4518)	info on Rv0409/ackA
Rv1791/PE19	(cc=0.4206)	info on Rv1791/PE19
Rv2758c/vapB21	(cc=0.4201)	info on Rv2758c/vapB21
Rv2311/-	(cc=0.411)	info on Rv2311/-
Rv0736/rslA	(cc=0.3994)	info on Rv0736/rslA
Rv0062/celA1	(cc=0.3989)	info on Rv0062/celA1
Rv3780/-	(cc=0.3982)	info on Rv3780/-
Rv0863/-	(cc=0.3961)	info on Rv0863/-
Rv1112/-	(cc=0.3942)	info on Rv1112/-
Rv0418/lpqL	(cc=0.3899)	info on Rv0418/lpqL

Correlation of Rv3441c/mrsA with Rv0736/rslA

Normalized LFCs for Rv3441c/mrsA:
(description and provenance of datasets)

	Rv3441c/mrsA	Rv0736/rslA
Fe_supp_jason_reseq	0.474	1.209
low_pH_jason_reseq	-0.634	0.44
NO_jason_reseq	-0.302	0.0
B6_jason_reseq	-0.421	0.0
MHCII_jason_reseq	-0.37	0.0
Isoniazid02	0.351	-0.113
Rifampicin4	0.341	0.912
Ethambutol3	0.293	0.336
Meropenem3	1.95	0.67
Vancomycin16	0.334	0.732
Rv2680_day32	0.0	0.0
H37Rv_KO_MarP	1.618	0.0
hypoxia_3wks	-0.55	0.0
hypoxia_6wks	-0.288	0.0
glycerol	0.385	0.0
cholesterol	0.0	0.0
AJ	0.0	0.0
Bibs02	1.123	0.0
Bibs02c	0.0	0.0
BL6	0.0	0.0
BL6a	0.0	0.0
BXD01	0.358	0.0
BXD010	0.244	0.0
BXD011	0.127	0.0
BXD03	0.0	0.0
BXD04	0.124	0.0
BXD05	0.0	0.0
BXD06	0.133	0.0
BXD07	0.138	0.0
BXD08	0.0	0.0
BXD09	0.0	0.0
CAST	0.0	0.0
CCcont	1.55	0.917
DS01	0.0	0.0
DS02	0.414	0.0
DS04	0.37	0.0
DS0c	0.0	0.0
GP01	0.0	0.0
GP02	0.0	0.0
GP0c	0.0	0.0
NOD	0.0	0.0
NZO	0.0	0.0
PWK	0.0	0.0
H37Rv_KO_CtpC	0.162	0.0
H37Rv_KO_CtpD	0.0	0.127
H37Rv_KO_Rv1272	0.0	0.0
H37Rv_KO_SugABC	0.0	0.0
H37Rv_KO_MbtN	0.0	0.103
Trans05	0.0	0.0
macrophage_unactivated	0.436	0.0
IL1	0.0	0.0
Rapamycin	0.0	0.0
Tcell	0.0	0.0
GMCSF	0.0	0.0
IFNab	0.0	0.0
IFNg	0.0	0.0
IFNg_GMCSF1	0.0	0.0
Rv1432_day32	0.0	0.0
Rv1565c_day32	0.0	0.0
secA2_input	0.197	2.843
delta_Rv3594	0.895	-0.555
delta_Rv3717	-0.331	-0.457
delta_Rv3811	-0.391	-0.644
delta_Rv0954	-0.34	-0.976
PonA1	-0.304	0.06
EccD1_KO	-0.378	-0.559
EspI_KO	-0.687	-2.025
PE35_KO	-1.105	-1.368
PPE68_KO	0.0	0.25
glycerol2	0.0	0.0
lignocerate	0.32	0.0
oleate	0.0	0.0
phosphatidylcholine	0.193	0.0
acetate	0.437	0.0
glucAc	0.501	0.0
Rv0950ko	0.0	0.0
Rv1096ko	0.905	1.167
Rv3684ko	0.0	0.982
delta_otsA_trehalose	-0.654	0.366