TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv3441c/mrsA:

update plot	correlation	link to info on gene
Rv0409/ackA	(cc=0.4518)	info on Rv0409/ackA
Rv1791/PE19	(cc=0.4206)	info on Rv1791/PE19
Rv2758c/vapB21	(cc=0.4201)	info on Rv2758c/vapB21
Rv2311/-	(cc=0.411)	info on Rv2311/-
Rv0736/rslA	(cc=0.3994)	info on Rv0736/rslA
Rv0062/celA1	(cc=0.3989)	info on Rv0062/celA1
Rv3780/-	(cc=0.3982)	info on Rv3780/-
Rv0863/-	(cc=0.3961)	info on Rv0863/-
Rv1112/-	(cc=0.3942)	info on Rv1112/-
Rv0418/lpqL	(cc=0.3899)	info on Rv0418/lpqL

Correlation of Rv3441c/mrsA with Rv0409/ackA

Normalized LFCs for Rv3441c/mrsA:
(description and provenance of datasets)

	Rv3441c/mrsA	Rv0409/ackA
Fe_supp_jason_reseq	0.474	0.868
low_pH_jason_reseq	-0.634	0.136
NO_jason_reseq	-0.302	0.315
B6_jason_reseq	-0.421	-0.581
MHCII_jason_reseq	-0.37	-0.541
Isoniazid02	0.351	0.112
Rifampicin4	0.341	0.0
Ethambutol3	0.293	2.079
Meropenem3	1.95	3.648
Vancomycin16	0.334	0.395
Rv2680_day32	0.0	0.362
H37Rv_KO_MarP	1.618	0.024
hypoxia_3wks	-0.55	0.152
hypoxia_6wks	-0.288	-0.827
glycerol	0.385	0.028
cholesterol	0.0	0.43
AJ	0.0	-0.919
Bibs02	1.123	1.699
Bibs02c	0.0	-0.411
BL6	0.0	0.507
BL6a	0.0	-0.199
BXD01	0.358	0.053
BXD010	0.244	0.589
BXD011	0.127	0.704
BXD03	0.0	-0.157
BXD04	0.124	-0.541
BXD05	0.0	0.909
BXD06	0.133	0.156
BXD07	0.138	-0.391
BXD08	0.0	0.514
BXD09	0.0	-0.502
CAST	0.0	-0.736
CCcont	1.55	0.04
DS01	0.0	0.821
DS02	0.414	0.484
DS04	0.37	0.343
DS0c	0.0	1.702
GP01	0.0	-0.496
GP02	0.0	-1.302
GP0c	0.0	0.152
NOD	0.0	-1.178
NZO	0.0	-0.6
PWK	0.0	-0.082
H37Rv_KO_CtpC	0.162	0.149
H37Rv_KO_CtpD	0.0	1.112
H37Rv_KO_Rv1272	0.0	-0.253
H37Rv_KO_SugABC	0.0	-1.071
H37Rv_KO_MbtN	0.0	0.446
Trans05	0.0	0.319
macrophage_unactivated	0.436	-0.486
IL1	0.0	0.16
Rapamycin	0.0	0.218
Tcell	0.0	-0.437
GMCSF	0.0	-1.048
IFNab	0.0	-0.59
IFNg	0.0	-0.305
IFNg_GMCSF1	0.0	-1.1
Rv1432_day32	0.0	-0.654
Rv1565c_day32	0.0	0.389
secA2_input	0.197	-0.205
delta_Rv3594	0.895	0.0
delta_Rv3717	-0.331	-0.047
delta_Rv3811	-0.391	-0.354
delta_Rv0954	-0.34	-0.121
PonA1	-0.304	0.611
EccD1_KO	-0.378	-0.276
EspI_KO	-0.687	-1.007
PE35_KO	-1.105	-0.461
PPE68_KO	0.0	-0.045
glycerol2	0.0	0.13
lignocerate	0.32	-0.213
oleate	0.0	-0.227
phosphatidylcholine	0.193	0.202
acetate	0.437	-0.451
glucAc	0.501	-0.693
Rv0950ko	0.0	-0.13
Rv1096ko	0.905	0.368
Rv3684ko	0.0	-0.141
delta_otsA_trehalose	-0.654	-0.965