TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv3268/-:

update plot	correlation	link to info on gene
Rv0380c/-	(cc=0.5052)	info on Rv0380c/-
Rv2321c/rocD2	(cc=0.4822)	info on Rv2321c/rocD2
Rv3537/kstD	(cc=0.4808)	info on Rv3537/kstD
Rv3692/moxR2	(cc=0.4797)	info on Rv3692/moxR2
Rv0576/-	(cc=0.4553)	info on Rv0576/-
Rv3840/-	(cc=0.4472)	info on Rv3840/-
Rv3036c/TB22.2	(cc=0.4444)	info on Rv3036c/TB22.2
Rv1830/-	(cc=0.4412)	info on Rv1830/-
Rv0209/-	(cc=0.4411)	info on Rv0209/-
Rv1128c/-	(cc=0.4198)	info on Rv1128c/-

Correlation of Rv3268/- with Rv3036c/TB22.2

Normalized LFCs for Rv3268/-:
(description and provenance of datasets)

	Rv3268/-	Rv3036c/TB22.2
Fe_supp_jason_reseq	0.069	0.137
low_pH_jason_reseq	-0.582	-1.253
NO_jason_reseq	-1.013	-1.307
B6_jason_reseq	-1.626	-2.542
MHCII_jason_reseq	-1.818	-1.684
Isoniazid02	-1.058	0.776
Rifampicin4	0.712	1.004
Ethambutol3	0.045	0.579
Meropenem3	-0.502	0.351
Vancomycin16	0.016	2.194
Rv2680_day32	-0.956	0.849
H37Rv_KO_MarP	0.586	0.207
hypoxia_3wks	0.55	1.595
hypoxia_6wks	1.274	2.359
glycerol	-0.543	0.904
cholesterol	-0.704	0.569
AJ	0.055	-0.798
Bibs02	0.278	-1.537
Bibs02c	-0.918	-0.517
BL6	0.0	1.455
BL6a	-0.242	1.046
BXD01	0.219	1.89
BXD010	0.274	1.676
BXD011	0.076	0.788
BXD03	0.459	0.942
BXD04	0.568	1.202
BXD05	0.288	2.048
BXD06	0.785	1.769
BXD07	-0.132	1.603
BXD08	0.16	0.951
BXD09	0.395	1.733
CAST	-0.329	-1.712
CCcont	-0.037	1.837
DS01	0.084	-2.084
DS02	-0.296	-2.96
DS04	-0.134	-0.96
DS0c	-0.135	-1.455
GP01	1.864	2.551
GP02	1.292	1.287
GP0c	0.297	2.192
NOD	-0.083	-2.4
NZO	-0.429	-0.764
PWK	-0.061	-1.12
H37Rv_KO_CtpC	-0.122	0.668
H37Rv_KO_CtpD	-0.933	0.0
H37Rv_KO_Rv1272	0.076	2.11
H37Rv_KO_SugABC	-0.372	0.408
H37Rv_KO_MbtN	0.21	1.906
Trans05	0.402	1.468
macrophage_unactivated	0.098	0.082
IL1	0.288	1.367
Rapamycin	0.939	0.755
Tcell	0.365	0.86
GMCSF	0.726	-0.549
IFNab	0.889	1.125
IFNg	0.337	1.267
IFNg_GMCSF1	0.657	0.283
Rv1432_day32	-0.271	1.551
Rv1565c_day32	0.289	-1.336
secA2_input	0.429	0.667
delta_Rv3594	0.304	0.701
delta_Rv3717	0.481	0.888
delta_Rv3811	0.894	0.72
delta_Rv0954	0.243	-1.557
PonA1	0.451	-1.101
EccD1_KO	0.168	-0.02
EspI_KO	-1.155	0.26
PE35_KO	0.128	-0.105
PPE68_KO	-0.739	0.397
glycerol2	0.276	-0.237
lignocerate	-0.018	-0.356
oleate	0.359	0.047
phosphatidylcholine	0.147	0.035
acetate	-0.243	0.439
glucAc	-0.327	0.295
Rv0950ko	0.163	0.217
Rv1096ko	0.368	-0.452
Rv3684ko	0.537	0.157
delta_otsA_trehalose	-1.794	-1.082