TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2458/mmuM:

update plot	correlation	link to info on gene
Rv2601/speE	(cc=0.5527)	info on Rv2601/speE
Rv0449c/-	(cc=0.5501)	info on Rv0449c/-
Rv2125/-	(cc=0.5414)	info on Rv2125/-
Rv3015c/-	(cc=0.5354)	info on Rv3015c/-
Rv3093c/-	(cc=0.5336)	info on Rv3093c/-
Rv1846c/blaI	(cc=0.5199)	info on Rv1846c/blaI
Rv3775/lipE	(cc=0.5015)	info on Rv3775/lipE
Rv2508c/-	(cc=0.4963)	info on Rv2508c/-
Rv0873/fadE10	(cc=0.4958)	info on Rv0873/fadE10
Rv2010/vapC15	(cc=0.4932)	info on Rv2010/vapC15

Correlation of Rv2458/mmuM with Rv0873/fadE10

Normalized LFCs for Rv2458/mmuM:
(description and provenance of datasets)

	Rv2458/mmuM	Rv0873/fadE10
Fe_supp_jason_reseq	0.775	0.892
low_pH_jason_reseq	-1.405	-1.044
NO_jason_reseq	-0.137	-0.732
B6_jason_reseq	0.127	0.425
MHCII_jason_reseq	1.203	0.675
Isoniazid02	-0.792	-0.908
Rifampicin4	-0.875	0.341
Ethambutol3	-0.694	-0.111
Meropenem3	0.244	-0.593
Vancomycin16	-0.968	-0.525
Rv2680_day32	0.72	0.514
H37Rv_KO_MarP	-0.15	0.306
hypoxia_3wks	0.171	-0.251
hypoxia_6wks	0.0	0.186
glycerol	0.0	0.184
cholesterol	-0.626	0.542
AJ	-0.074	-0.178
Bibs02	-0.409	-0.282
Bibs02c	0.221	0.673
BL6	-0.884	0.014
BL6a	-0.02	0.485
BXD01	-0.746	0.187
BXD010	-0.602	-0.229
BXD011	-0.85	-0.084
BXD03	-0.719	-0.209
BXD04	-0.849	0.271
BXD05	-0.654	0.411
BXD06	-0.908	0.055
BXD07	-0.643	0.113
BXD08	-0.252	0.251
BXD09	-0.447	-0.015
CAST	-0.14	-0.34
CCcont	-0.901	-0.065
DS01	0.25	0.394
DS02	0.153	0.487
DS04	0.046	0.08
DS0c	0.25	0.448
GP01	0.735	0.584
GP02	1.183	1.007
GP0c	-0.084	0.131
NOD	0.0	-0.387
NZO	0.101	0.123
PWK	-0.2	-0.185
H37Rv_KO_CtpC	-0.141	-0.342
H37Rv_KO_CtpD	-0.23	0.489
H37Rv_KO_Rv1272	-0.28	0.61
H37Rv_KO_SugABC	0.407	0.11
H37Rv_KO_MbtN	-0.635	0.058
Trans05	-0.572	-0.131
macrophage_unactivated	0.571	0.253
IL1	0.409	-0.374
Rapamycin	0.126	-0.285
Tcell	-0.749	0.072
GMCSF	0.943	0.341
IFNab	0.339	-0.209
IFNg	1.026	0.139
IFNg_GMCSF1	0.644	-0.396
Rv1432_day32	0.638	0.175
Rv1565c_day32	0.1	-0.708
secA2_input	0.229	-0.131
delta_Rv3594	0.355	0.459
delta_Rv3717	0.333	0.0
delta_Rv3811	0.846	0.446
delta_Rv0954	0.957	0.377
PonA1	1.23	0.521
EccD1_KO	0.654	0.28
EspI_KO	0.781	0.67
PE35_KO	0.37	0.137
PPE68_KO	0.208	0.0
glycerol2	0.336	0.46
lignocerate	-0.096	0.201
oleate	0.417	0.6
phosphatidylcholine	0.137	0.51
acetate	-0.479	-0.298
glucAc	-0.921	-0.621
Rv0950ko	0.38	0.021
Rv1096ko	-0.932	-0.486
Rv3684ko	-0.098	-0.501
delta_otsA_trehalose	0.364	0.97