TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2246/kasB:

update plot	correlation	link to info on gene
Rv2198c/mmpS3	(cc=0.7108)	info on Rv2198c/mmpS3
Rv2256c/-	(cc=0.6853)	info on Rv2256c/-
Rv0541c/-	(cc=0.6757)	info on Rv0541c/-
Rv1512/epiA	(cc=0.6749)	info on Rv1512/epiA
Rv1080c/greA	(cc=0.674)	info on Rv1080c/greA
Rv3044/fecB	(cc=0.6578)	info on Rv3044/fecB
Rv2837c/-	(cc=0.6329)	info on Rv2837c/-
Rv2400c/subI	(cc=0.6236)	info on Rv2400c/subI
Rv2131c/cysQ	(cc=0.607)	info on Rv2131c/cysQ
Rv3764c/tcrY	(cc=0.6042)	info on Rv3764c/tcrY

Correlation of Rv2246/kasB with Rv1080c/greA

Normalized LFCs for Rv2246/kasB:
(description and provenance of datasets)

	Rv2246/kasB	Rv1080c/greA
Fe_supp_jason_reseq	0.766	1.121
low_pH_jason_reseq	0.0	-0.231
NO_jason_reseq	0.0	0.633
B6_jason_reseq	0.0	0.267
MHCII_jason_reseq	0.0	-0.135
Isoniazid02	-0.119	-0.851
Rifampicin4	-1.922	-0.271
Ethambutol3	-0.711	0.505
Meropenem3	-0.701	-0.12
Vancomycin16	-1.884	-0.546
Rv2680_day32	0.0	0.0
H37Rv_KO_MarP	-1.984	-2.138
hypoxia_3wks	0.55	-0.55
hypoxia_6wks	0.549	0.503
glycerol	0.0	-0.385
cholesterol	0.0	0.233
AJ	0.0	0.193
Bibs02	0.0	-0.167
Bibs02c	0.0	-0.399
BL6	0.0	-0.114
BL6a	0.198	0.319
BXD01	0.13	-0.119
BXD010	0.0	0.299
BXD011	0.0	0.383
BXD03	0.0	-0.123
BXD04	0.0	0.199
BXD05	0.135	0.57
BXD06	0.0	0.0
BXD07	0.68	0.0
BXD08	0.0	0.111
BXD09	0.268	0.117
CAST	0.0	-0.21
CCcont	1.366	1.481
DS01	0.0	-0.216
DS02	0.0	-0.414
DS04	0.682	0.312
DS0c	0.0	0.349
GP01	0.0	0.672
GP02	0.0	-0.159
GP0c	0.0	0.551
NOD	0.0	0.361
NZO	0.0	0.0
PWK	0.0	0.0
H37Rv_KO_CtpC	0.162	0.261
H37Rv_KO_CtpD	0.127	0.381
H37Rv_KO_Rv1272	0.0	-0.129
H37Rv_KO_SugABC	0.487	0.083
H37Rv_KO_MbtN	0.633	2.002
Trans05	0.0	0.889
macrophage_unactivated	-0.363	0.436
IL1	0.317	0.0
Rapamycin	-0.74	0.0
Tcell	-0.785	0.0
GMCSF	0.0	0.0
IFNab	0.323	0.0
IFNg	0.286	0.0
IFNg_GMCSF1	0.647	0.0
Rv1432_day32	0.0	1.068
Rv1565c_day32	0.0	0.218
secA2_input	2.243	-0.348
delta_Rv3594	3.841	3.356
delta_Rv3717	3.949	3.97
delta_Rv3811	1.878	3.554
delta_Rv0954	3.517	-2.225
PonA1	0.0	-1.428
EccD1_KO	-4.177	-3.029
EspI_KO	-2.205	-1.825
PE35_KO	-0.913	-1.747
PPE68_KO	-0.23	-0.755
glycerol2	0.0	0.0
lignocerate	0.0	0.0
oleate	0.0	0.0
phosphatidylcholine	0.0	0.0
acetate	0.0	0.0
glucAc	0.0	0.0
Rv0950ko	-3.242	-3.35
Rv1096ko	-4.931	-1.888
Rv3684ko	-0.783	-0.655
delta_otsA_trehalose	0.0	0.906