TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2077c/-:

update plot	correlation	link to info on gene
Rv1781c/malQ	(cc=0.588)	info on Rv1781c/malQ
Rv3738c/PPE66	(cc=0.537)	info on Rv3738c/PPE66
Rv3688c/-	(cc=0.5317)	info on Rv3688c/-
Rv1103c/mazE3	(cc=0.5285)	info on Rv1103c/mazE3
Rv2390c/-	(cc=0.526)	info on Rv2390c/-
Rv0194/-	(cc=0.5153)	info on Rv0194/-
Rv1045/-	(cc=0.4897)	info on Rv1045/-
Rv2602/vapC41	(cc=0.4682)	info on Rv2602/vapC41
Rv1263/amiB2	(cc=0.4636)	info on Rv1263/amiB2
Rv0572c/-	(cc=0.4501)	info on Rv0572c/-

Correlation of Rv2077c/- with Rv1103c/mazE3

Normalized LFCs for Rv2077c/-:
(description and provenance of datasets)

	Rv2077c/-	Rv1103c/mazE3
Fe_supp_jason_reseq	-0.658	-0.594
low_pH_jason_reseq	-0.442	-0.902
NO_jason_reseq	0.249	0.213
B6_jason_reseq	0.26	0.133
MHCII_jason_reseq	-0.431	0.223
Isoniazid02	-0.18	-0.067
Rifampicin4	0.043	0.152
Ethambutol3	-0.505	-0.213
Meropenem3	-0.181	0.217
Vancomycin16	-0.143	-0.138
Rv2680_day32	0.272	0.746
H37Rv_KO_MarP	0.113	-0.294
hypoxia_3wks	0.355	-0.136
hypoxia_6wks	0.198	0.898
glycerol	-0.357	-0.328
cholesterol	-0.385	-0.873
AJ	0.161	-0.212
Bibs02	0.465	0.29
Bibs02c	-0.064	-0.191
BL6	0.336	0.168
BL6a	0.116	-0.281
BXD01	-0.309	-0.334
BXD010	-0.019	-0.512
BXD011	-0.142	-0.171
BXD03	-0.295	0.198
BXD04	-0.317	0.787
BXD05	-0.128	-0.005
BXD06	-0.031	-0.366
BXD07	-0.215	-0.348
BXD08	0.13	-0.95
BXD09	0.032	0.239
CAST	-0.367	0.224
CCcont	-0.148	0.286
DS01	-0.195	-0.084
DS02	-0.243	-0.199
DS04	0.195	1.228
DS0c	-0.556	0.09
GP01	0.514	-0.405
GP02	0.626	0.599
GP0c	0.205	0.347
NOD	-0.096	-1.311
NZO	-0.101	-0.064
PWK	0.409	0.502
H37Rv_KO_CtpC	0.304	-0.271
H37Rv_KO_CtpD	0.53	0.638
H37Rv_KO_Rv1272	0.412	0.458
H37Rv_KO_SugABC	0.799	1.39
H37Rv_KO_MbtN	0.307	0.508
Trans05	0.764	0.503
macrophage_unactivated	-0.06	-0.253
IL1	0.294	0.332
Rapamycin	-0.325	0.644
Tcell	-0.463	-0.515
GMCSF	-0.227	-1.112
IFNab	0.042	-0.55
IFNg	0.345	0.016
IFNg_GMCSF1	-0.544	-0.456
Rv1432_day32	0.143	1.095
Rv1565c_day32	0.103	0.689
secA2_input	0.158	0.188
delta_Rv3594	-0.323	0.797
delta_Rv3717	-0.339	0.968
delta_Rv3811	-0.03	0.949
delta_Rv0954	0.388	1.762
PonA1	0.055	0.792
EccD1_KO	-0.464	-0.201
EspI_KO	-0.268	0.61
PE35_KO	-1.024	-0.913
PPE68_KO	-0.819	-0.675
glycerol2	0.928	1.767
lignocerate	0.906	2.366
oleate	0.808	-0.605
phosphatidylcholine	1.206	1.831
acetate	0.527	2.031
glucAc	0.385	2.196
Rv0950ko	0.525	0.271
Rv1096ko	0.036	0.0
Rv3684ko	0.393	-0.54
delta_otsA_trehalose	0.628	-0.098