TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1922/-:

update plot	correlation	link to info on gene
Rv1864c/-	(cc=0.5435)	info on Rv1864c/-
Rv3401/-	(cc=0.5281)	info on Rv3401/-
Rv1250/-	(cc=0.4582)	info on Rv1250/-
Rv3309c/upp	(cc=0.4561)	info on Rv3309c/upp
Rv0894/-	(cc=0.4548)	info on Rv0894/-
Rv2466c/-	(cc=0.4504)	info on Rv2466c/-
Rv1563c/treY	(cc=0.4463)	info on Rv1563c/treY
Rv1554/frdC	(cc=0.4457)	info on Rv1554/frdC
Rv0846c/-	(cc=0.4443)	info on Rv0846c/-
Rv1453/-	(cc=0.4436)	info on Rv1453/-

Correlation of Rv1922/- with Rv1554/frdC

Normalized LFCs for Rv1922/-:
(description and provenance of datasets)

	Rv1922/-	Rv1554/frdC
Fe_supp_jason_reseq	0.025	-0.125
low_pH_jason_reseq	0.204	0.497
NO_jason_reseq	-0.609	-0.333
B6_jason_reseq	0.558	1.17
MHCII_jason_reseq	0.843	0.359
Isoniazid02	-0.105	0.054
Rifampicin4	-0.829	0.328
Ethambutol3	-0.207	0.139
Meropenem3	0.688	-0.158
Vancomycin16	-0.769	-0.244
Rv2680_day32	0.395	0.035
H37Rv_KO_MarP	-0.025	0.377
hypoxia_3wks	0.136	0.977
hypoxia_6wks	-0.035	1.472
glycerol	0.301	0.187
cholesterol	0.743	0.847
AJ	0.264	-0.071
Bibs02	0.103	0.522
Bibs02c	-0.408	0.5
BL6	0.117	-0.352
BL6a	-0.507	0.643
BXD01	-0.715	0.13
BXD010	-0.064	0.88
BXD011	0.394	0.297
BXD03	-0.915	-0.195
BXD04	-0.366	0.212
BXD05	-0.248	0.648
BXD06	-0.477	0.271
BXD07	-0.584	0.442
BXD08	-0.491	1.1
BXD09	-0.574	0.546
CAST	0.404	0.0
CCcont	-0.865	-0.376
DS01	0.527	0.977
DS02	0.35	0.682
DS04	0.059	0.308
DS0c	1.095	0.908
GP01	0.451	0.888
GP02	-0.271	0.49
GP0c	-0.575	-0.328
NOD	0.361	0.099
NZO	0.321	0.733
PWK	-0.126	0.571
H37Rv_KO_CtpC	-0.52	0.173
H37Rv_KO_CtpD	0.093	1.074
H37Rv_KO_Rv1272	-0.026	0.957
H37Rv_KO_SugABC	-0.444	0.243
H37Rv_KO_MbtN	0.668	0.13
Trans05	0.404	1.146
macrophage_unactivated	0.0	0.758
IL1	-0.234	0.534
Rapamycin	-0.896	0.552
Tcell	-0.228	0.274
GMCSF	0.198	0.246
IFNab	-0.348	0.378
IFNg	-0.409	0.5
IFNg_GMCSF1	0.079	0.729
Rv1432_day32	0.413	0.789
Rv1565c_day32	0.329	0.809
secA2_input	-1.229	-1.088
delta_Rv3594	0.012	0.837
delta_Rv3717	-0.395	0.59
delta_Rv3811	-0.086	-0.042
delta_Rv0954	0.189	0.372
PonA1	-0.261	0.182
EccD1_KO	0.497	1.95
EspI_KO	-0.277	0.625
PE35_KO	0.75	1.301
PPE68_KO	1.113	0.966
glycerol2	-0.388	-0.343
lignocerate	-0.337	-0.446
oleate	-0.058	-0.121
phosphatidylcholine	-0.289	-0.381
acetate	-0.209	-0.56
glucAc	-0.642	-0.739
Rv0950ko	-0.142	0.256
Rv1096ko	-0.112	-0.799
Rv3684ko	-0.278	-0.982
delta_otsA_trehalose	0.522	0.076