TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1598c/-:

update plot	correlation	link to info on gene
Rv1776c/-	(cc=0.5725)	info on Rv1776c/-
Rv0844c/narL	(cc=0.5699)	info on Rv0844c/narL
Rv2545/vapB18	(cc=0.5142)	info on Rv2545/vapB18
Rv0131c/fadE1	(cc=0.5109)	info on Rv0131c/fadE1
Rv2071c/cobM	(cc=0.4988)	info on Rv2071c/cobM
Rv3628/ppa	(cc=0.4878)	info on Rv3628/ppa
Rv2548A/-	(cc=0.4811)	info on Rv2548A/-
Rv1871c/-	(cc=0.475)	info on Rv1871c/-
Rv1583c/-	(cc=0.4559)	info on Rv1583c/-
Rv3036c/TB22.2	(cc=0.4446)	info on Rv3036c/TB22.2

Correlation of Rv1598c/- with Rv3036c/TB22.2

Normalized LFCs for Rv1598c/-:
(description and provenance of datasets)

	Rv1598c/-	Rv3036c/TB22.2
Fe_supp_jason_reseq	-0.101	0.137
low_pH_jason_reseq	-0.43	-1.253
NO_jason_reseq	-0.57	-1.307
B6_jason_reseq	-2.25	-2.542
MHCII_jason_reseq	-1.365	-1.684
Isoniazid02	0.898	0.776
Rifampicin4	0.057	1.004
Ethambutol3	0.026	0.579
Meropenem3	-0.277	0.351
Vancomycin16	0.454	2.194
Rv2680_day32	0.78	0.849
H37Rv_KO_MarP	-0.257	0.207
hypoxia_3wks	-0.658	1.595
hypoxia_6wks	0.752	2.359
glycerol	0.929	0.904
cholesterol	0.624	0.569
AJ	-0.392	-0.798
Bibs02	0.156	-1.537
Bibs02c	-0.676	-0.517
BL6	1.5	1.455
BL6a	-0.09	1.046
BXD01	0.571	1.89
BXD010	1.393	1.676
BXD011	1.554	0.788
BXD03	0.357	0.942
BXD04	-0.79	1.202
BXD05	0.195	2.048
BXD06	0.155	1.769
BXD07	0.045	1.603
BXD08	0.523	0.951
BXD09	-0.165	1.733
CAST	0.587	-1.712
CCcont	0.61	1.837
DS01	0.128	-2.084
DS02	-0.703	-2.96
DS04	0.146	-0.96
DS0c	-0.453	-1.455
GP01	0.226	2.551
GP02	-1.152	1.287
GP0c	0.765	2.192
NOD	-0.076	-2.4
NZO	-1.49	-0.764
PWK	-0.547	-1.12
H37Rv_KO_CtpC	-0.171	0.668
H37Rv_KO_CtpD	1.076	0.0
H37Rv_KO_Rv1272	1.206	2.11
H37Rv_KO_SugABC	0.894	0.408
H37Rv_KO_MbtN	1.943	1.906
Trans05	1.179	1.468
macrophage_unactivated	0.249	0.082
IL1	0.068	1.367
Rapamycin	-0.611	0.755
Tcell	-0.114	0.86
GMCSF	0.121	-0.549
IFNab	-0.142	1.125
IFNg	-0.428	1.267
IFNg_GMCSF1	-0.148	0.283
Rv1432_day32	0.566	1.551
Rv1565c_day32	0.163	-1.336
secA2_input	1.295	0.667
delta_Rv3594	-1.872	0.701
delta_Rv3717	-0.799	0.888
delta_Rv3811	-1.224	0.72
delta_Rv0954	-1.976	-1.557
PonA1	-0.998	-1.101
EccD1_KO	0.043	-0.02
EspI_KO	1.146	0.26
PE35_KO	1.4	-0.105
PPE68_KO	0.669	0.397
glycerol2	0.07	-0.237
lignocerate	0.36	-0.356
oleate	0.449	0.047
phosphatidylcholine	0.265	0.035
acetate	0.424	0.439
glucAc	-0.403	0.295
Rv0950ko	0.531	0.217
Rv1096ko	0.0	-0.452
Rv3684ko	-0.072	0.157
delta_otsA_trehalose	-1.62	-1.082