TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1598c/-:

update plot	correlation	link to info on gene
Rv1776c/-	(cc=0.5725)	info on Rv1776c/-
Rv0844c/narL	(cc=0.5699)	info on Rv0844c/narL
Rv2545/vapB18	(cc=0.5142)	info on Rv2545/vapB18
Rv0131c/fadE1	(cc=0.5109)	info on Rv0131c/fadE1
Rv2071c/cobM	(cc=0.4988)	info on Rv2071c/cobM
Rv3628/ppa	(cc=0.4878)	info on Rv3628/ppa
Rv2548A/-	(cc=0.4811)	info on Rv2548A/-
Rv1871c/-	(cc=0.475)	info on Rv1871c/-
Rv1583c/-	(cc=0.4559)	info on Rv1583c/-
Rv3036c/TB22.2	(cc=0.4446)	info on Rv3036c/TB22.2

Correlation of Rv1598c/- with Rv2548A/-

Normalized LFCs for Rv1598c/-:
(description and provenance of datasets)

	Rv1598c/-	Rv2548A/-
Fe_supp_jason_reseq	-0.101	0.0
low_pH_jason_reseq	-0.43	0.0
NO_jason_reseq	-0.57	0.0
B6_jason_reseq	-2.25	0.0
MHCII_jason_reseq	-1.365	0.0
Isoniazid02	0.898	0.469
Rifampicin4	0.057	1.362
Ethambutol3	0.026	0.0
Meropenem3	-0.277	0.266
Vancomycin16	0.454	0.854
Rv2680_day32	0.78	0.0
H37Rv_KO_MarP	-0.257	-0.34
hypoxia_3wks	-0.658	0.0
hypoxia_6wks	0.752	0.0
glycerol	0.929	0.0
cholesterol	0.624	0.0
AJ	-0.392	0.0
Bibs02	0.156	0.0
Bibs02c	-0.676	0.0
BL6	1.5	0.0
BL6a	-0.09	0.0
BXD01	0.571	0.0
BXD010	1.393	0.0
BXD011	1.554	0.0
BXD03	0.357	0.0
BXD04	-0.79	0.0
BXD05	0.195	0.0
BXD06	0.155	0.0
BXD07	0.045	0.0
BXD08	0.523	0.0
BXD09	-0.165	0.0
CAST	0.587	0.0
CCcont	0.61	0.0
DS01	0.128	0.0
DS02	-0.703	0.0
DS04	0.146	0.0
DS0c	-0.453	0.0
GP01	0.226	0.0
GP02	-1.152	0.0
GP0c	0.765	0.0
NOD	-0.076	0.0
NZO	-1.49	0.0
PWK	-0.547	0.0
H37Rv_KO_CtpC	-0.171	0.0
H37Rv_KO_CtpD	1.076	0.0
H37Rv_KO_Rv1272	1.206	0.0
H37Rv_KO_SugABC	0.894	0.0
H37Rv_KO_MbtN	1.943	0.362
Trans05	1.179	0.0
macrophage_unactivated	0.249	0.0
IL1	0.068	0.0
Rapamycin	-0.611	0.0
Tcell	-0.114	0.0
GMCSF	0.121	0.0
IFNab	-0.142	0.0
IFNg	-0.428	0.0
IFNg_GMCSF1	-0.148	0.0
Rv1432_day32	0.566	0.0
Rv1565c_day32	0.163	0.0
secA2_input	1.295	1.853
delta_Rv3594	-1.872	-2.287
delta_Rv3717	-0.799	-2.054
delta_Rv3811	-1.224	-1.05
delta_Rv0954	-1.976	-2.109
PonA1	-0.998	-1.884
EccD1_KO	0.043	-0.454
EspI_KO	1.146	0.0
PE35_KO	1.4	0.0
PPE68_KO	0.669	1.113
glycerol2	0.07	0.0
lignocerate	0.36	0.0
oleate	0.449	0.0
phosphatidylcholine	0.265	0.0
acetate	0.424	0.0
glucAc	-0.403	0.0
Rv0950ko	0.531	0.416
Rv1096ko	0.0	0.0
Rv3684ko	-0.072	0.0
delta_otsA_trehalose	-1.62	0.0