TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1598c/-:

update plot	correlation	link to info on gene
Rv1776c/-	(cc=0.5725)	info on Rv1776c/-
Rv0844c/narL	(cc=0.5699)	info on Rv0844c/narL
Rv2545/vapB18	(cc=0.5142)	info on Rv2545/vapB18
Rv0131c/fadE1	(cc=0.5109)	info on Rv0131c/fadE1
Rv2071c/cobM	(cc=0.4988)	info on Rv2071c/cobM
Rv3628/ppa	(cc=0.4878)	info on Rv3628/ppa
Rv2548A/-	(cc=0.4811)	info on Rv2548A/-
Rv1871c/-	(cc=0.475)	info on Rv1871c/-
Rv1583c/-	(cc=0.4559)	info on Rv1583c/-
Rv3036c/TB22.2	(cc=0.4446)	info on Rv3036c/TB22.2

Correlation of Rv1598c/- with Rv1776c/-

Normalized LFCs for Rv1598c/-:
(description and provenance of datasets)

	Rv1598c/-	Rv1776c/-
Fe_supp_jason_reseq	-0.101	-1.105
low_pH_jason_reseq	-0.43	0.264
NO_jason_reseq	-0.57	1.436
B6_jason_reseq	-2.25	-2.347
MHCII_jason_reseq	-1.365	-0.461
Isoniazid02	0.898	1.366
Rifampicin4	0.057	-0.141
Ethambutol3	0.026	0.732
Meropenem3	-0.277	0.761
Vancomycin16	0.454	0.045
Rv2680_day32	0.78	-0.116
H37Rv_KO_MarP	-0.257	0.032
hypoxia_3wks	-0.658	-0.1
hypoxia_6wks	0.752	0.722
glycerol	0.929	0.671
cholesterol	0.624	0.773
AJ	-0.392	0.05
Bibs02	0.156	0.115
Bibs02c	-0.676	0.297
BL6	1.5	0.879
BL6a	-0.09	0.428
BXD01	0.571	0.533
BXD010	1.393	0.579
BXD011	1.554	0.866
BXD03	0.357	-0.53
BXD04	-0.79	1.174
BXD05	0.195	-0.059
BXD06	0.155	0.862
BXD07	0.045	0.957
BXD08	0.523	0.601
BXD09	-0.165	1.003
CAST	0.587	0.192
CCcont	0.61	0.797
DS01	0.128	0.51
DS02	-0.703	0.391
DS04	0.146	-1.166
DS0c	-0.453	0.544
GP01	0.226	0.433
GP02	-1.152	-0.603
GP0c	0.765	1.301
NOD	-0.076	-0.952
NZO	-1.49	0.533
PWK	-0.547	-0.534
H37Rv_KO_CtpC	-0.171	-0.309
H37Rv_KO_CtpD	1.076	-1.298
H37Rv_KO_Rv1272	1.206	0.807
H37Rv_KO_SugABC	0.894	1.451
H37Rv_KO_MbtN	1.943	0.978
Trans05	1.179	1.879
macrophage_unactivated	0.249	1.18
IL1	0.068	0.721
Rapamycin	-0.611	0.0
Tcell	-0.114	1.883
GMCSF	0.121	0.549
IFNab	-0.142	-0.317
IFNg	-0.428	0.107
IFNg_GMCSF1	-0.148	-2.168
Rv1432_day32	0.566	0.915
Rv1565c_day32	0.163	1.057
secA2_input	1.295	1.709
delta_Rv3594	-1.872	-2.481
delta_Rv3717	-0.799	-1.114
delta_Rv3811	-1.224	-0.968
delta_Rv0954	-1.976	-2.746
PonA1	-0.998	-1.041
EccD1_KO	0.043	0.76
EspI_KO	1.146	-0.183
PE35_KO	1.4	0.178
PPE68_KO	0.669	0.131
glycerol2	0.07	0.181
lignocerate	0.36	0.608
oleate	0.449	-0.634
phosphatidylcholine	0.265	0.3
acetate	0.424	0.063
glucAc	-0.403	0.187
Rv0950ko	0.531	0.338
Rv1096ko	0.0	-0.06
Rv3684ko	-0.072	-0.4
delta_otsA_trehalose	-1.62	-1.811