TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1498A/-:

update plot	correlation	link to info on gene
Rv2519/PE26	(cc=0.5856)	info on Rv2519/PE26
Rv2548/vapC19	(cc=0.544)	info on Rv2548/vapC19
Rv1217c/-	(cc=0.5413)	info on Rv1217c/-
Rv1729c/-	(cc=0.5307)	info on Rv1729c/-
Rv0505c/serB1	(cc=0.5054)	info on Rv0505c/serB1
Rv1548c/PPE21	(cc=0.4837)	info on Rv1548c/PPE21
Rv1583c/-	(cc=0.4738)	info on Rv1583c/-
Rv1507c/-	(cc=0.4673)	info on Rv1507c/-
Rv2735c/-	(cc=0.4619)	info on Rv2735c/-
Rv2818c/-	(cc=0.4595)	info on Rv2818c/-

Correlation of Rv1498A/- with Rv1507c/-

Normalized LFCs for Rv1498A/-:
(description and provenance of datasets)

	Rv1498A/-	Rv1507c/-
Fe_supp_jason_reseq	0.684	-0.712
low_pH_jason_reseq	0.0	0.795
NO_jason_reseq	0.48	-0.709
B6_jason_reseq	-1.941	-0.5
MHCII_jason_reseq	-1.531	-0.815
Isoniazid02	0.15	0.14
Rifampicin4	0.474	0.734
Ethambutol3	0.409	0.564
Meropenem3	0.21	0.274
Vancomycin16	0.515	0.828
Rv2680_day32	0.973	0.0
H37Rv_KO_MarP	-0.418	-0.157
hypoxia_3wks	-0.299	0.79
hypoxia_6wks	0.015	0.637
glycerol	-0.159	-0.607
cholesterol	-0.348	-0.773
AJ	-1.805	1.287
Bibs02	-0.91	0.348
Bibs02c	-0.133	-0.112
BL6	0.571	-0.138
BL6a	0.56	1.329
BXD01	-0.669	0.458
BXD010	0.357	0.244
BXD011	0.505	0.666
BXD03	0.198	1.115
BXD04	-0.866	0.434
BXD05	0.76	1.448
BXD06	-0.085	1.131
BXD07	0.513	1.267
BXD08	0.116	0.778
BXD09	0.448	1.346
CAST	-0.472	-0.39
CCcont	-0.341	0.733
DS01	-0.351	0.346
DS02	0.101	0.11
DS04	-0.753	-0.104
DS0c	-2.861	0.317
GP01	0.436	0.837
GP02	-0.236	-0.25
GP0c	0.528	0.76
NOD	-1.681	0.329
NZO	0.139	-0.22
PWK	-0.709	0.374
H37Rv_KO_CtpC	1.027	1.655
H37Rv_KO_CtpD	2.402	2.232
H37Rv_KO_Rv1272	0.64	0.946
H37Rv_KO_SugABC	0.644	2.191
H37Rv_KO_MbtN	-0.596	0.799
Trans05	1.133	1.251
macrophage_unactivated	-0.83	-0.092
IL1	-0.323	0.4
Rapamycin	-0.319	0.571
Tcell	-1.401	0.179
GMCSF	-0.227	-0.077
IFNab	-0.78	-0.088
IFNg	-0.433	0.147
IFNg_GMCSF1	-1.775	-0.273
Rv1432_day32	0.374	0.662
Rv1565c_day32	1.031	0.0
secA2_input	-2.661	-1.021
delta_Rv3594	-0.28	0.34
delta_Rv3717	-0.634	-0.405
delta_Rv3811	0.326	-0.665
delta_Rv0954	-0.315	-0.34
PonA1	-1.297	0.054
EccD1_KO	-1.342	0.171
EspI_KO	-1.03	0.95
PE35_KO	0.613	0.152
PPE68_KO	-0.787	0.0
glycerol2	-1.956	-0.38
lignocerate	-0.912	-0.213
oleate	-1.062	-0.315
phosphatidylcholine	-0.825	0.0
acetate	0.239	-0.904
glucAc	-0.19	-0.229
Rv0950ko	-0.745	0.513
Rv1096ko	-1.535	-0.739
Rv3684ko	-2.161	-0.802
delta_otsA_trehalose	-0.792	0.711