TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1173/fbiC:

update plot	correlation	link to info on gene
Rv3262/fbiB	(cc=0.7971)	info on Rv3262/fbiB
Rv3261/fbiA	(cc=0.753)	info on Rv3261/fbiA
Rv2983/-	(cc=0.745)	info on Rv2983/-
Rv0860/fadB	(cc=0.6757)	info on Rv0860/fadB
Rv3624c/hpt	(cc=0.6639)	info on Rv3624c/hpt
Rv0392c/ndhA	(cc=0.6551)	info on Rv0392c/ndhA
Rv1908c/katG	(cc=0.628)	info on Rv1908c/katG
Rv3193c/-	(cc=0.6258)	info on Rv3193c/-
Rv2909c/rpsP	(cc=0.6257)	info on Rv2909c/rpsP
Rv2543/lppA	(cc=0.5912)	info on Rv2543/lppA

Correlation of Rv1173/fbiC with Rv2983/-

Normalized LFCs for Rv1173/fbiC:
(description and provenance of datasets)

	Rv1173/fbiC	Rv2983/-
Fe_supp_jason_reseq	0.8	0.218
low_pH_jason_reseq	0.124	0.0
NO_jason_reseq	-0.42	0.0
B6_jason_reseq	0.16	0.292
MHCII_jason_reseq	0.27	0.135
Isoniazid02	2.424	2.89
Rifampicin4	0.931	2.142
Ethambutol3	1.147	1.249
Meropenem3	1.23	0.189
Vancomycin16	0.546	2.183
Rv2680_day32	-1.189	0.0
H37Rv_KO_MarP	-0.412	1.112
hypoxia_3wks	-0.478	-0.502
hypoxia_6wks	-1.539	-0.549
glycerol	1.128	0.856
cholesterol	0.583	1.504
AJ	0.513	0.232
Bibs02	0.0	0.0
Bibs02c	0.355	0.209
BL6	-0.456	0.0
BL6a	0.336	0.0
BXD01	0.151	0.0
BXD010	-0.168	0.0
BXD011	-0.167	0.0
BXD03	0.08	0.0
BXD04	-0.347	0.0
BXD05	-0.176	0.135
BXD06	0.155	0.133
BXD07	0.373	0.0
BXD08	-0.485	0.0
BXD09	0.163	0.0
CAST	-0.302	0.0
CCcont	1.832	1.082
DS01	1.783	1.947
DS02	1.134	0.0
DS04	1.834	0.194
DS0c	1.287	0.596
GP01	-0.548	0.0
GP02	-0.462	0.0
GP0c	-0.591	0.0
NOD	-0.295	0.0
NZO	-0.262	0.0
PWK	-0.398	0.0
H37Rv_KO_CtpC	0.785	0.0
H37Rv_KO_CtpD	1.374	0.127
H37Rv_KO_Rv1272	0.445	0.0
H37Rv_KO_SugABC	0.168	0.099
H37Rv_KO_MbtN	0.866	0.0
Trans05	0.631	0.0
macrophage_unactivated	0.783	0.0
IL1	0.258	0.0
Rapamycin	0.0	0.0
Tcell	0.554	0.0
GMCSF	1.035	0.0
IFNab	0.0	0.0
IFNg	-0.516	0.0
IFNg_GMCSF1	0.534	0.0
Rv1432_day32	-0.164	0.0
Rv1565c_day32	0.986	0.0
secA2_input	-1.154	-0.485
delta_Rv3594	0.422	1.811
delta_Rv3717	-1.688	0.0
delta_Rv3811	0.457	0.934
delta_Rv0954	1.388	0.811
PonA1	0.919	1.367
EccD1_KO	-1.273	-0.664
EspI_KO	-0.516	-1.243
PE35_KO	1.508	1.52
PPE68_KO	0.595	1.667
glycerol2	-1.645	-1.297
lignocerate	-3.039	-2.345
oleate	-2.915	-2.358
phosphatidylcholine	-3.808	-2.697
acetate	0.203	-1.102
glucAc	-0.246	-1.49
Rv0950ko	-0.546	-1.294
Rv1096ko	-1.034	-0.256
Rv3684ko	-1.055	-0.727
delta_otsA_trehalose	0.414	-0.111