TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1151c/-:

update plot	correlation	link to info on gene
Rv0270/fadD2	(cc=0.5714)	info on Rv0270/fadD2
Rv2187/fadD15	(cc=0.5079)	info on Rv2187/fadD15
Rv1206/fadD6	(cc=0.4845)	info on Rv1206/fadD6
Rv3263/-	(cc=0.4782)	info on Rv3263/-
Rv2905/lppW	(cc=0.4382)	info on Rv2905/lppW
Rv1646/PE17	(cc=0.4363)	info on Rv1646/PE17
Rv0554/bpoC	(cc=0.4302)	info on Rv0554/bpoC
Rv1487/-	(cc=0.4291)	info on Rv1487/-
Rv2450c/rpfE	(cc=0.4264)	info on Rv2450c/rpfE
Rv2332/mez	(cc=0.4257)	info on Rv2332/mez

Correlation of Rv1151c/- with Rv3263/-

Normalized LFCs for Rv1151c/-:
(description and provenance of datasets)

	Rv1151c/-	Rv3263/-
Fe_supp_jason_reseq	-1.088	-1.905
low_pH_jason_reseq	0.719	-0.959
NO_jason_reseq	1.793	0.837
B6_jason_reseq	1.64	0.922
MHCII_jason_reseq	-0.121	-0.43
Isoniazid02	0.631	-0.489
Rifampicin4	-0.089	0.16
Ethambutol3	0.486	0.758
Meropenem3	0.332	0.109
Vancomycin16	-0.088	-0.695
Rv2680_day32	-0.173	-0.234
H37Rv_KO_MarP	0.231	-0.452
hypoxia_3wks	-0.203	-0.247
hypoxia_6wks	-0.601	0.578
glycerol	-0.413	-0.582
cholesterol	-0.426	-0.775
AJ	0.79	-0.21
Bibs02	0.412	-0.609
Bibs02c	0.273	-0.332
BL6	0.323	0.115
BL6a	0.263	-0.258
BXD01	0.458	0.184
BXD010	0.232	0.337
BXD011	0.707	1.005
BXD03	0.603	0.09
BXD04	0.366	0.789
BXD05	-0.113	0.495
BXD06	1.066	0.821
BXD07	0.716	0.652
BXD08	1.429	0.599
BXD09	0.297	0.19
CAST	1.657	1.431
CCcont	-0.713	-1.225
DS01	0.633	-0.944
DS02	0.583	-0.731
DS04	0.502	-0.682
DS0c	-0.08	-1.051
GP01	-1.312	0.595
GP02	-0.391	0.579
GP0c	-1.32	0.048
NOD	0.984	0.044
NZO	1.261	0.621
PWK	2.998	1.826
H37Rv_KO_CtpC	1.286	1.37
H37Rv_KO_CtpD	-0.857	0.098
H37Rv_KO_Rv1272	-0.255	-0.939
H37Rv_KO_SugABC	0.431	0.037
H37Rv_KO_MbtN	0.025	0.144
Trans05	0.493	0.422
macrophage_unactivated	-0.846	-1.591
IL1	-0.196	0.027
Rapamycin	-1.31	-0.789
Tcell	1.29	0.469
GMCSF	-1.022	-0.325
IFNab	-1.886	-1.094
IFNg	0.045	0.457
IFNg_GMCSF1	-0.666	0.39
Rv1432_day32	2.523	1.272
Rv1565c_day32	-0.785	-1.303
secA2_input	0.384	0.507
delta_Rv3594	0.216	0.381
delta_Rv3717	0.326	0.79
delta_Rv3811	-0.494	0.272
delta_Rv0954	0.474	0.044
PonA1	0.239	-0.117
EccD1_KO	1.25	0.467
EspI_KO	1.757	-0.057
PE35_KO	1.771	0.222
PPE68_KO	1.577	0.042
glycerol2	0.706	0.905
lignocerate	0.634	0.463
oleate	4.229	-0.22
phosphatidylcholine	0.894	1.006
acetate	0.208	-0.12
glucAc	0.069	0.277
Rv0950ko	-0.428	0.645
Rv1096ko	-0.784	0.193
Rv3684ko	0.383	0.901
delta_otsA_trehalose	0.371	0.021