TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1151c/-:

update plot	correlation	link to info on gene
Rv0270/fadD2	(cc=0.5714)	info on Rv0270/fadD2
Rv2187/fadD15	(cc=0.5079)	info on Rv2187/fadD15
Rv1206/fadD6	(cc=0.4845)	info on Rv1206/fadD6
Rv3263/-	(cc=0.4782)	info on Rv3263/-
Rv2905/lppW	(cc=0.4382)	info on Rv2905/lppW
Rv1646/PE17	(cc=0.4363)	info on Rv1646/PE17
Rv0554/bpoC	(cc=0.4302)	info on Rv0554/bpoC
Rv1487/-	(cc=0.4291)	info on Rv1487/-
Rv2450c/rpfE	(cc=0.4264)	info on Rv2450c/rpfE
Rv2332/mez	(cc=0.4257)	info on Rv2332/mez

Correlation of Rv1151c/- with Rv2187/fadD15

Normalized LFCs for Rv1151c/-:
(description and provenance of datasets)

	Rv1151c/-	Rv2187/fadD15
Fe_supp_jason_reseq	-1.088	-0.534
low_pH_jason_reseq	0.719	-0.303
NO_jason_reseq	1.793	1.124
B6_jason_reseq	1.64	0.165
MHCII_jason_reseq	-0.121	-0.597
Isoniazid02	0.631	0.349
Rifampicin4	-0.089	0.16
Ethambutol3	0.486	-0.011
Meropenem3	0.332	-0.023
Vancomycin16	-0.088	-0.406
Rv2680_day32	-0.173	0.836
H37Rv_KO_MarP	0.231	0.526
hypoxia_3wks	-0.203	0.132
hypoxia_6wks	-0.601	0.069
glycerol	-0.413	-0.566
cholesterol	-0.426	-0.14
AJ	0.79	0.748
Bibs02	0.412	-0.132
Bibs02c	0.273	-0.162
BL6	0.323	-0.034
BL6a	0.263	0.261
BXD01	0.458	0.445
BXD010	0.232	0.405
BXD011	0.707	0.521
BXD03	0.603	0.103
BXD04	0.366	0.201
BXD05	-0.113	0.775
BXD06	1.066	0.581
BXD07	0.716	0.301
BXD08	1.429	0.632
BXD09	0.297	0.407
CAST	1.657	1.44
CCcont	-0.713	-0.279
DS01	0.633	-0.356
DS02	0.583	-0.169
DS04	0.502	0.669
DS0c	-0.08	0.093
GP01	-1.312	0.286
GP02	-0.391	0.328
GP0c	-1.32	0.151
NOD	0.984	0.527
NZO	1.261	0.517
PWK	2.998	0.877
H37Rv_KO_CtpC	1.286	-0.173
H37Rv_KO_CtpD	-0.857	-0.006
H37Rv_KO_Rv1272	-0.255	-0.324
H37Rv_KO_SugABC	0.431	0.547
H37Rv_KO_MbtN	0.025	-0.046
Trans05	0.493	1.157
macrophage_unactivated	-0.846	0.161
IL1	-0.196	0.19
Rapamycin	-1.31	0.27
Tcell	1.29	0.384
GMCSF	-1.022	0.185
IFNab	-1.886	-0.478
IFNg	0.045	0.444
IFNg_GMCSF1	-0.666	0.179
Rv1432_day32	2.523	1.572
Rv1565c_day32	-0.785	-0.625
secA2_input	0.384	-0.376
delta_Rv3594	0.216	0.355
delta_Rv3717	0.326	0.456
delta_Rv3811	-0.494	0.274
delta_Rv0954	0.474	-0.477
PonA1	0.239	-0.417
EccD1_KO	1.25	0.691
EspI_KO	1.757	-0.068
PE35_KO	1.771	0.633
PPE68_KO	1.577	0.25
glycerol2	0.706	0.595
lignocerate	0.634	0.598
oleate	4.229	0.872
phosphatidylcholine	0.894	0.626
acetate	0.208	-0.033
glucAc	0.069	0.868
Rv0950ko	-0.428	-0.308
Rv1096ko	-0.784	0.048
Rv3684ko	0.383	0.262
delta_otsA_trehalose	0.371	-0.626