TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1151c/-:

update plot	correlation	link to info on gene
Rv0270/fadD2	(cc=0.5714)	info on Rv0270/fadD2
Rv2187/fadD15	(cc=0.5079)	info on Rv2187/fadD15
Rv1206/fadD6	(cc=0.4845)	info on Rv1206/fadD6
Rv3263/-	(cc=0.4782)	info on Rv3263/-
Rv2905/lppW	(cc=0.4382)	info on Rv2905/lppW
Rv1646/PE17	(cc=0.4363)	info on Rv1646/PE17
Rv0554/bpoC	(cc=0.4302)	info on Rv0554/bpoC
Rv1487/-	(cc=0.4291)	info on Rv1487/-
Rv2450c/rpfE	(cc=0.4264)	info on Rv2450c/rpfE
Rv2332/mez	(cc=0.4257)	info on Rv2332/mez

Correlation of Rv1151c/- with Rv1646/PE17

Normalized LFCs for Rv1151c/-:
(description and provenance of datasets)

	Rv1151c/-	Rv1646/PE17
Fe_supp_jason_reseq	-1.088	0.358
low_pH_jason_reseq	0.719	-0.348
NO_jason_reseq	1.793	0.181
B6_jason_reseq	1.64	0.787
MHCII_jason_reseq	-0.121	0.025
Isoniazid02	0.631	0.661
Rifampicin4	-0.089	0.439
Ethambutol3	0.486	0.48
Meropenem3	0.332	-0.279
Vancomycin16	-0.088	-0.167
Rv2680_day32	-0.173	0.621
H37Rv_KO_MarP	0.231	-0.195
hypoxia_3wks	-0.203	0.267
hypoxia_6wks	-0.601	-0.654
glycerol	-0.413	0.329
cholesterol	-0.426	0.325
AJ	0.79	0.948
Bibs02	0.412	0.13
Bibs02c	0.273	0.606
BL6	0.323	-0.783
BL6a	0.263	0.445
BXD01	0.458	0.031
BXD010	0.232	-0.225
BXD011	0.707	-0.667
BXD03	0.603	-0.788
BXD04	0.366	0.394
BXD05	-0.113	-0.054
BXD06	1.066	-0.508
BXD07	0.716	-0.498
BXD08	1.429	0.082
BXD09	0.297	-0.457
CAST	1.657	1.018
CCcont	-0.713	-0.333
DS01	0.633	0.631
DS02	0.583	0.597
DS04	0.502	0.396
DS0c	-0.08	1.196
GP01	-1.312	0.043
GP02	-0.391	0.312
GP0c	-1.32	0.025
NOD	0.984	0.765
NZO	1.261	0.525
PWK	2.998	0.479
H37Rv_KO_CtpC	1.286	0.071
H37Rv_KO_CtpD	-0.857	-0.623
H37Rv_KO_Rv1272	-0.255	-0.306
H37Rv_KO_SugABC	0.431	-0.135
H37Rv_KO_MbtN	0.025	0.468
Trans05	0.493	-0.072
macrophage_unactivated	-0.846	-0.729
IL1	-0.196	-1.103
Rapamycin	-1.31	-1.264
Tcell	1.29	-0.026
GMCSF	-1.022	-0.855
IFNab	-1.886	-1.403
IFNg	0.045	-1.213
IFNg_GMCSF1	-0.666	-0.698
Rv1432_day32	2.523	-0.339
Rv1565c_day32	-0.785	-0.488
secA2_input	0.384	-0.067
delta_Rv3594	0.216	0.219
delta_Rv3717	0.326	-0.447
delta_Rv3811	-0.494	0.089
delta_Rv0954	0.474	-0.167
PonA1	0.239	0.194
EccD1_KO	1.25	0.49
EspI_KO	1.757	0.351
PE35_KO	1.771	0.397
PPE68_KO	1.577	0.873
glycerol2	0.706	0.573
lignocerate	0.634	0.32
oleate	4.229	0.763
phosphatidylcholine	0.894	0.882
acetate	0.208	-0.253
glucAc	0.069	-0.363
Rv0950ko	-0.428	0.606
Rv1096ko	-0.784	-0.817
Rv3684ko	0.383	-0.321
delta_otsA_trehalose	0.371	-1.123