TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1147/-:

update plot	correlation	link to info on gene
Rv2505c/fadD35	(cc=0.5326)	info on Rv2505c/fadD35
Rv2504c/scoA	(cc=0.4527)	info on Rv2504c/scoA
Rv1424c/-	(cc=0.4204)	info on Rv1424c/-
Rv2136c/-	(cc=0.417)	info on Rv2136c/-
Rv2820c/-	(cc=0.4123)	info on Rv2820c/-
Rv2295/-	(cc=0.4111)	info on Rv2295/-
Rv3730c/-	(cc=0.4053)	info on Rv3730c/-
Rv1215c/-	(cc=0.3918)	info on Rv1215c/-
Rv2424c/-	(cc=0.3876)	info on Rv2424c/-
Rv1768/PE_PGRS31	(cc=0.3851)	info on Rv1768/PE_PGRS31

Correlation of Rv1147/- with Rv2295/-

Normalized LFCs for Rv1147/-:
(description and provenance of datasets)

	Rv1147/-	Rv2295/-
Fe_supp_jason_reseq	-0.039	-0.469
low_pH_jason_reseq	-0.368	-0.375
NO_jason_reseq	-0.131	-0.27
B6_jason_reseq	-0.353	-0.341
MHCII_jason_reseq	-0.281	0.692
Isoniazid02	0.326	0.183
Rifampicin4	0.536	0.341
Ethambutol3	2.456	1.262
Meropenem3	-0.47	-0.152
Vancomycin16	0.478	0.281
Rv2680_day32	-0.257	-1.558
H37Rv_KO_MarP	0.316	-0.33
hypoxia_3wks	0.475	0.128
hypoxia_6wks	0.461	0.117
glycerol	-0.462	-0.645
cholesterol	0.315	-0.305
AJ	-0.602	0.373
Bibs02	-0.338	0.734
Bibs02c	-0.591	-0.343
BL6	0.492	-0.798
BL6a	-0.188	-0.261
BXD01	-0.746	-0.029
BXD010	0.46	0.438
BXD011	0.138	0.34
BXD03	-0.26	-0.443
BXD04	-0.093	-0.622
BXD05	-0.446	0.13
BXD06	0.23	0.102
BXD07	0.017	0.32
BXD08	0.914	-0.488
BXD09	-0.332	-0.132
CAST	0.148	-0.956
CCcont	-0.678	-0.737
DS01	0.66	0.426
DS02	1.588	0.914
DS04	0.294	1.126
DS0c	0.248	-0.025
GP01	1.042	-0.561
GP02	0.567	-0.228
GP0c	0.439	-0.213
NOD	-0.617	-0.877
NZO	-0.611	0.487
PWK	0.307	-0.102
H37Rv_KO_CtpC	-0.187	-0.647
H37Rv_KO_CtpD	-1.179	0.386
H37Rv_KO_Rv1272	-0.467	-0.843
H37Rv_KO_SugABC	0.581	0.555
H37Rv_KO_MbtN	1.214	0.062
Trans05	0.069	0.504
macrophage_unactivated	-0.903	-1.266
IL1	0.0	-0.507
Rapamycin	0.525	-0.525
Tcell	-0.472	-1.131
GMCSF	0.069	-0.23
IFNab	-0.027	-0.813
IFNg	-0.094	-0.094
IFNg_GMCSF1	0.0	-1.32
Rv1432_day32	1.754	0.683
Rv1565c_day32	1.249	0.096
secA2_input	1.171	0.866
delta_Rv3594	-1.075	1.075
delta_Rv3717	-0.51	0.31
delta_Rv3811	0.146	0.787
delta_Rv0954	-0.238	0.889
PonA1	0.275	0.891
EccD1_KO	1.74	0.687
EspI_KO	1.246	1.229
PE35_KO	0.685	0.61
PPE68_KO	0.822	1.353
glycerol2	-0.279	-0.084
lignocerate	-0.068	-0.464
oleate	-0.196	0.159
phosphatidylcholine	-0.16	-0.457
acetate	-0.15	-0.667
glucAc	-0.474	0.211
Rv0950ko	-0.464	0.326
Rv1096ko	-1.273	-0.404
Rv3684ko	-1.248	-1.153
delta_otsA_trehalose	-0.339	0.356