TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1147/-:

update plot	correlation	link to info on gene
Rv2505c/fadD35	(cc=0.5326)	info on Rv2505c/fadD35
Rv2504c/scoA	(cc=0.4527)	info on Rv2504c/scoA
Rv1424c/-	(cc=0.4204)	info on Rv1424c/-
Rv2136c/-	(cc=0.417)	info on Rv2136c/-
Rv2820c/-	(cc=0.4123)	info on Rv2820c/-
Rv2295/-	(cc=0.4111)	info on Rv2295/-
Rv3730c/-	(cc=0.4053)	info on Rv3730c/-
Rv1215c/-	(cc=0.3918)	info on Rv1215c/-
Rv2424c/-	(cc=0.3876)	info on Rv2424c/-
Rv1768/PE_PGRS31	(cc=0.3851)	info on Rv1768/PE_PGRS31

Correlation of Rv1147/- with Rv1215c/-

Normalized LFCs for Rv1147/-:
(description and provenance of datasets)

	Rv1147/-	Rv1215c/-
Fe_supp_jason_reseq	-0.039	-0.272
low_pH_jason_reseq	-0.368	0.11
NO_jason_reseq	-0.131	0.339
B6_jason_reseq	-0.353	-0.613
MHCII_jason_reseq	-0.281	-1.388
Isoniazid02	0.326	0.755
Rifampicin4	0.536	0.441
Ethambutol3	2.456	2.03
Meropenem3	-0.47	0.919
Vancomycin16	0.478	0.276
Rv2680_day32	-0.257	0.171
H37Rv_KO_MarP	0.316	0.334
hypoxia_3wks	0.475	0.622
hypoxia_6wks	0.461	0.0
glycerol	-0.462	-0.127
cholesterol	0.315	0.069
AJ	-0.602	0.536
Bibs02	-0.338	-0.399
Bibs02c	-0.591	-0.488
BL6	0.492	0.418
BL6a	-0.188	0.141
BXD01	-0.746	0.339
BXD010	0.46	0.527
BXD011	0.138	1.165
BXD03	-0.26	0.172
BXD04	-0.093	0.158
BXD05	-0.446	0.27
BXD06	0.23	0.515
BXD07	0.017	0.25
BXD08	0.914	0.743
BXD09	-0.332	0.53
CAST	0.148	0.509
CCcont	-0.678	0.054
DS01	0.66	0.058
DS02	1.588	0.323
DS04	0.294	0.093
DS0c	0.248	0.079
GP01	1.042	0.529
GP02	0.567	1.583
GP0c	0.439	0.077
NOD	-0.617	-0.172
NZO	-0.611	0.98
PWK	0.307	0.117
H37Rv_KO_CtpC	-0.187	0.721
H37Rv_KO_CtpD	-1.179	0.5
H37Rv_KO_Rv1272	-0.467	0.837
H37Rv_KO_SugABC	0.581	-0.024
H37Rv_KO_MbtN	1.214	0.297
Trans05	0.069	0.601
macrophage_unactivated	-0.903	-0.186
IL1	0.0	-0.264
Rapamycin	0.525	-0.181
Tcell	-0.472	0.14
GMCSF	0.069	-0.037
IFNab	-0.027	0.088
IFNg	-0.094	-0.238
IFNg_GMCSF1	0.0	-0.632
Rv1432_day32	1.754	1.285
Rv1565c_day32	1.249	0.092
secA2_input	1.171	-0.604
delta_Rv3594	-1.075	-0.194
delta_Rv3717	-0.51	-0.932
delta_Rv3811	0.146	-0.598
delta_Rv0954	-0.238	-0.872
PonA1	0.275	-0.016
EccD1_KO	1.74	0.457
EspI_KO	1.246	0.311
PE35_KO	0.685	0.405
PPE68_KO	0.822	0.253
glycerol2	-0.279	-0.031
lignocerate	-0.068	-0.054
oleate	-0.196	0.593
phosphatidylcholine	-0.16	0.539
acetate	-0.15	-0.409
glucAc	-0.474	-0.644
Rv0950ko	-0.464	-0.347
Rv1096ko	-1.273	0.042
Rv3684ko	-1.248	-0.331
delta_otsA_trehalose	-0.339	-0.673