TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1012/-:

update plot	correlation	link to info on gene
Rv2020c/-	(cc=0.5169)	info on Rv2020c/-
Rv3482c/-	(cc=0.4805)	info on Rv3482c/-
Rv0044c/-	(cc=0.4694)	info on Rv0044c/-
Rv0325/-	(cc=0.4644)	info on Rv0325/-
Rv2076c/-	(cc=0.4616)	info on Rv2076c/-
Rv2382c/mbtC	(cc=0.4565)	info on Rv2382c/mbtC
Rv2651c/-	(cc=0.4451)	info on Rv2651c/-
Rv2064/cobG	(cc=0.4387)	info on Rv2064/cobG
Rv1858/modB	(cc=0.4378)	info on Rv1858/modB
Rv1632c/-	(cc=0.4376)	info on Rv1632c/-

Correlation of Rv1012/- with Rv1632c/-

Normalized LFCs for Rv1012/-:
(description and provenance of datasets)

	Rv1012/-	Rv1632c/-
Fe_supp_jason_reseq	1.274	-1.19
low_pH_jason_reseq	-0.572	0.231
NO_jason_reseq	-0.714	0.239
B6_jason_reseq	1.353	0.772
MHCII_jason_reseq	0.593	0.957
Isoniazid02	0.509	1.787
Rifampicin4	0.441	0.043
Ethambutol3	2.008	1.718
Meropenem3	1.366	0.201
Vancomycin16	0.528	0.21
Rv2680_day32	-2.215	0.098
H37Rv_KO_MarP	-0.229	0.202
hypoxia_3wks	-0.068	0.227
hypoxia_6wks	0.624	0.38
glycerol	-0.044	-0.085
cholesterol	0.682	-0.711
AJ	0.903	0.571
Bibs02	-0.185	0.244
Bibs02c	-0.418	0.258
BL6	0.255	0.169
BL6a	-1.511	-0.189
BXD01	0.0	-0.713
BXD010	-0.502	-1.353
BXD011	-1.364	-0.411
BXD03	-1.125	-2.036
BXD04	-1.287	-1.527
BXD05	-1.78	-1.091
BXD06	-0.385	-0.89
BXD07	-0.286	-0.601
BXD08	0.18	-0.921
BXD09	-0.435	-0.986
CAST	1.155	0.032
CCcont	0.123	-1.21
DS01	1.03	0.168
DS02	1.119	-0.187
DS04	-0.197	0.402
DS0c	0.746	0.514
GP01	0.403	0.403
GP02	-0.819	-1.133
GP0c	0.236	-0.764
NOD	0.408	0.091
NZO	0.776	0.613
PWK	0.834	0.193
H37Rv_KO_CtpC	-0.65	-1.184
H37Rv_KO_CtpD	-1.724	0.282
H37Rv_KO_Rv1272	-0.632	0.52
H37Rv_KO_SugABC	-0.218	0.138
H37Rv_KO_MbtN	-0.797	-1.736
Trans05	-0.872	-0.696
macrophage_unactivated	1.095	-0.565
IL1	0.276	-0.842
Rapamycin	0.199	-0.908
Tcell	0.091	-0.531
GMCSF	0.752	0.013
IFNab	0.03	-0.989
IFNg	1.216	-0.107
IFNg_GMCSF1	0.204	-0.339
Rv1432_day32	0.08	0.656
Rv1565c_day32	-0.147	-0.629
secA2_input	-0.817	-0.935
delta_Rv3594	-0.024	0.555
delta_Rv3717	1.279	0.218
delta_Rv3811	-0.122	0.225
delta_Rv0954	0.735	-0.136
PonA1	0.832	0.976
EccD1_KO	1.237	0.319
EspI_KO	-0.471	0.348
PE35_KO	0.222	-0.388
PPE68_KO	-1.232	-0.426
glycerol2	1.516	0.092
lignocerate	1.241	0.401
oleate	0.142	0.859
phosphatidylcholine	1.053	0.539
acetate	0.77	0.08
glucAc	0.449	-0.126
Rv0950ko	-0.479	-0.805
Rv1096ko	-0.651	-0.739
Rv3684ko	-1.32	-0.757
delta_otsA_trehalose	0.263	-1.151