TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0873/fadE10:

update plot	correlation	link to info on gene
Rv1916/aceAb	(cc=0.5323)	info on Rv1916/aceAb
Rv2458/mmuM	(cc=0.4958)	info on Rv2458/mmuM
Rv2429/ahpD	(cc=0.4783)	info on Rv2429/ahpD
Rv1981c/nrdF1	(cc=0.4731)	info on Rv1981c/nrdF1
Rv2408/PE24	(cc=0.4723)	info on Rv2408/PE24
Rv3116/moeB2	(cc=0.4628)	info on Rv3116/moeB2
Rv1511/gmdA	(cc=0.4612)	info on Rv1511/gmdA
Rv2345/-	(cc=0.4515)	info on Rv2345/-
Rv0713/-	(cc=0.4466)	info on Rv0713/-
Rv0978c/PE_PGRS17	(cc=0.4276)	info on Rv0978c/PE_PGRS17

Correlation of Rv0873/fadE10 with Rv2429/ahpD

Normalized LFCs for Rv0873/fadE10:
(description and provenance of datasets)

	Rv0873/fadE10	Rv2429/ahpD
Fe_supp_jason_reseq	0.892	0.174
low_pH_jason_reseq	-1.044	-0.867
NO_jason_reseq	-0.732	0.0
B6_jason_reseq	0.425	0.363
MHCII_jason_reseq	0.675	1.557
Isoniazid02	-0.908	-4.061
Rifampicin4	0.341	0.171
Ethambutol3	-0.111	0.32
Meropenem3	-0.593	-0.819
Vancomycin16	-0.525	0.167
Rv2680_day32	0.514	-0.016
H37Rv_KO_MarP	0.306	0.567
hypoxia_3wks	-0.251	0.311
hypoxia_6wks	0.186	0.464
glycerol	0.184	0.178
cholesterol	0.542	0.015
AJ	-0.178	0.513
Bibs02	-0.282	0.212
Bibs02c	0.673	1.36
BL6	0.014	0.58
BL6a	0.485	1.118
BXD01	0.187	0.56
BXD010	-0.229	-0.448
BXD011	-0.084	-0.123
BXD03	-0.209	0.107
BXD04	0.271	0.418
BXD05	0.411	0.719
BXD06	0.055	0.053
BXD07	0.113	0.822
BXD08	0.251	0.04
BXD09	-0.015	-0.044
CAST	-0.34	-0.072
CCcont	-0.065	0.816
DS01	0.394	0.0
DS02	0.487	0.534
DS04	0.08	-0.37
DS0c	0.448	0.718
GP01	0.584	0.509
GP02	1.007	-1.258
GP0c	0.131	-1.082
NOD	-0.387	0.57
NZO	0.123	-0.481
PWK	-0.185	0.155
H37Rv_KO_CtpC	-0.342	-0.592
H37Rv_KO_CtpD	0.489	0.751
H37Rv_KO_Rv1272	0.61	0.029
H37Rv_KO_SugABC	0.11	0.283
H37Rv_KO_MbtN	0.058	0.401
Trans05	-0.131	1.134
macrophage_unactivated	0.253	0.294
IL1	-0.374	-1.006
Rapamycin	-0.285	0.083
Tcell	0.072	-0.228
GMCSF	0.341	1.014
IFNab	-0.209	-0.085
IFNg	0.139	0.732
IFNg_GMCSF1	-0.396	0.17
Rv1432_day32	0.175	0.9
Rv1565c_day32	-0.708	0.147
secA2_input	-0.131	-2.016
delta_Rv3594	0.459	1.462
delta_Rv3717	0.0	0.132
delta_Rv3811	0.446	1.077
delta_Rv0954	0.377	1.145
PonA1	0.521	0.709
EccD1_KO	0.28	-0.756
EspI_KO	0.67	0.171
PE35_KO	0.137	0.502
PPE68_KO	0.0	0.963
glycerol2	0.46	0.943
lignocerate	0.201	0.839
oleate	0.6	0.818
phosphatidylcholine	0.51	0.796
acetate	-0.298	0.519
glucAc	-0.621	0.423
Rv0950ko	0.021	-0.853
Rv1096ko	-0.486	-1.668
Rv3684ko	-0.501	-1.723
delta_otsA_trehalose	0.97	1.015