TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0873/fadE10:

update plot	correlation	link to info on gene
Rv1916/aceAb	(cc=0.5323)	info on Rv1916/aceAb
Rv2458/mmuM	(cc=0.4958)	info on Rv2458/mmuM
Rv2429/ahpD	(cc=0.4783)	info on Rv2429/ahpD
Rv1981c/nrdF1	(cc=0.4731)	info on Rv1981c/nrdF1
Rv2408/PE24	(cc=0.4723)	info on Rv2408/PE24
Rv3116/moeB2	(cc=0.4628)	info on Rv3116/moeB2
Rv1511/gmdA	(cc=0.4612)	info on Rv1511/gmdA
Rv2345/-	(cc=0.4515)	info on Rv2345/-
Rv0713/-	(cc=0.4466)	info on Rv0713/-
Rv0978c/PE_PGRS17	(cc=0.4276)	info on Rv0978c/PE_PGRS17

Correlation of Rv0873/fadE10 with Rv2345/-

Normalized LFCs for Rv0873/fadE10:
(description and provenance of datasets)

	Rv0873/fadE10	Rv2345/-
Fe_supp_jason_reseq	0.892	-0.019
low_pH_jason_reseq	-1.044	-0.962
NO_jason_reseq	-0.732	-0.053
B6_jason_reseq	0.425	-0.063
MHCII_jason_reseq	0.675	0.065
Isoniazid02	-0.908	-1.199
Rifampicin4	0.341	0.509
Ethambutol3	-0.111	-1.019
Meropenem3	-0.593	-1.409
Vancomycin16	-0.525	-0.655
Rv2680_day32	0.514	-0.466
H37Rv_KO_MarP	0.306	-0.02
hypoxia_3wks	-0.251	0.032
hypoxia_6wks	0.186	0.257
glycerol	0.184	0.192
cholesterol	0.542	-0.086
AJ	-0.178	0.0
Bibs02	-0.282	-0.278
Bibs02c	0.673	-0.205
BL6	0.014	0.138
BL6a	0.485	0.118
BXD01	0.187	0.14
BXD010	-0.229	0.141
BXD011	-0.084	-0.262
BXD03	-0.209	-0.04
BXD04	0.271	0.291
BXD05	0.411	0.374
BXD06	0.055	0.147
BXD07	0.113	0.238
BXD08	0.251	0.434
BXD09	-0.015	0.199
CAST	-0.34	-0.225
CCcont	-0.065	0.024
DS01	0.394	0.0
DS02	0.487	-0.498
DS04	0.08	-0.142
DS0c	0.448	-0.057
GP01	0.584	0.277
GP02	1.007	0.072
GP0c	0.131	0.147
NOD	-0.387	0.265
NZO	0.123	-0.237
PWK	-0.185	-0.058
H37Rv_KO_CtpC	-0.342	0.373
H37Rv_KO_CtpD	0.489	0.605
H37Rv_KO_Rv1272	0.61	0.291
H37Rv_KO_SugABC	0.11	0.767
H37Rv_KO_MbtN	0.058	0.628
Trans05	-0.131	0.501
macrophage_unactivated	0.253	-0.114
IL1	-0.374	0.338
Rapamycin	-0.285	0.473
Tcell	0.072	0.039
GMCSF	0.341	0.599
IFNab	-0.209	0.311
IFNg	0.139	0.216
IFNg_GMCSF1	-0.396	0.182
Rv1432_day32	0.175	0.194
Rv1565c_day32	-0.708	0.175
secA2_input	-0.131	0.233
delta_Rv3594	0.459	0.271
delta_Rv3717	0.0	0.055
delta_Rv3811	0.446	0.352
delta_Rv0954	0.377	0.371
PonA1	0.521	-0.321
EccD1_KO	0.28	0.704
EspI_KO	0.67	0.767
PE35_KO	0.137	0.429
PPE68_KO	0.0	0.176
glycerol2	0.46	0.277
lignocerate	0.201	0.284
oleate	0.6	0.702
phosphatidylcholine	0.51	0.153
acetate	-0.298	-0.462
glucAc	-0.621	-0.232
Rv0950ko	0.021	0.434
Rv1096ko	-0.486	-0.567
Rv3684ko	-0.501	-0.54
delta_otsA_trehalose	0.97	0.582