TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0784/-:

update plot	correlation	link to info on gene
Rv1331/-	(cc=0.5182)	info on Rv1331/-
Rv1541c/lprI	(cc=0.4815)	info on Rv1541c/lprI
Rv3556c/fadA6	(cc=0.447)	info on Rv3556c/fadA6
Rv3536c/hsaE	(cc=0.4457)	info on Rv3536c/hsaE
Rv1208/gpgS	(cc=0.4448)	info on Rv1208/gpgS
Rv2912c/-	(cc=0.4321)	info on Rv2912c/-
Rv0411c/glnH	(cc=0.4203)	info on Rv0411c/glnH
Rv1282c/oppC	(cc=0.4189)	info on Rv1282c/oppC
Rv0837c/-	(cc=0.4186)	info on Rv0837c/-
Rv2380c/mbtE	(cc=0.4166)	info on Rv2380c/mbtE

Correlation of Rv0784/- with Rv1208/gpgS

Normalized LFCs for Rv0784/-:
(description and provenance of datasets)

	Rv0784/-	Rv1208/gpgS
Fe_supp_jason_reseq	0.83	0.0
low_pH_jason_reseq	1.673	0.0
NO_jason_reseq	1.053	0.0
B6_jason_reseq	1.077	0.0
MHCII_jason_reseq	-0.315	0.0
Isoniazid02	0.0	0.0
Rifampicin4	1.394	0.0
Ethambutol3	0.235	0.0
Meropenem3	0.35	0.0
Vancomycin16	0.899	0.0
Rv2680_day32	0.023	0.0
H37Rv_KO_MarP	0.936	0.0
hypoxia_3wks	-1.101	0.0
hypoxia_6wks	0.0	0.0
glycerol	-0.108	0.0
cholesterol	-0.246	0.0
AJ	0.0	0.0
Bibs02	0.348	0.0
Bibs02c	-0.629	0.0
BL6	-0.212	0.0
BL6a	0.1	0.0
BXD01	0.066	0.0
BXD010	-0.478	0.0
BXD011	-0.297	0.0
BXD03	-0.072	0.0
BXD04	-0.372	0.0
BXD05	-0.405	0.0
BXD06	0.566	0.0
BXD07	-0.517	0.0
BXD08	1.856	0.0
BXD09	-0.075	0.0
CAST	-0.692	0.0
CCcont	0.633	0.149
DS01	0.45	0.0
DS02	1.207	0.0
DS04	1.456	0.0
DS0c	0.762	0.0
GP01	0.099	0.0
GP02	0.323	0.0
GP0c	0.248	0.0
NOD	-0.675	0.0
NZO	1.107	0.0
PWK	0.0	0.0
H37Rv_KO_CtpC	1.219	0.0
H37Rv_KO_CtpD	0.241	0.0
H37Rv_KO_Rv1272	1.321	0.0
H37Rv_KO_SugABC	2.627	0.0
H37Rv_KO_MbtN	0.437	0.0
Trans05	1.43	0.0
macrophage_unactivated	3.156	0.0
IL1	0.19	0.0
Rapamycin	-0.424	0.0
Tcell	-0.218	0.0
GMCSF	1.18	0.0
IFNab	1.052	0.0
IFNg	3.009	0.0
IFNg_GMCSF1	1.555	0.0
Rv1432_day32	0.0	0.0
Rv1565c_day32	1.633	0.0
secA2_input	-1.498	-1.234
delta_Rv3594	2.324	0.0
delta_Rv3717	1.375	0.0
delta_Rv3811	0.721	0.0
delta_Rv0954	1.292	0.178
PonA1	2.829	0.0
EccD1_KO	1.993	0.454
EspI_KO	1.842	1.383
PE35_KO	2.535	2.234
PPE68_KO	2.438	2.451
glycerol2	0.238	0.0
lignocerate	1.271	0.0
oleate	-0.961	0.0
phosphatidylcholine	0.549	0.0
acetate	1.662	0.0
glucAc	1.607	0.272
Rv0950ko	-0.416	0.416
Rv1096ko	1.632	0.416
Rv3684ko	3.347	1.241
delta_otsA_trehalose	-1.121	0.133