TB Genome Annotation Portal

Rv0411c (glnH)

• Current annotations:
  • TBCAP: (community-based annotations - see table at bottom of page)
  • TBDB: polar amino acid transporter substrate-binding protein
  • REFSEQ: glutamine-binding lipoprotein
  • PATRIC: Glutamine ABC transporter periplasmic glutamine-binding protein (TC 3.A.1.3.2)
  • TUBERCULIST: Probable glutamine-binding lipoprotein GlnH (GLNBP)
  • NCBI: Probable glutamine-binding lipoprotein GlnH (GLNBP)
  • updated information (H37Rv4):
    • gene name: glnH
    • function:
    • reference:
• Type: Not Target
• Start: 497314
• End: 498300
• Operon:


• Trans-membrane region:
  
• Role: III.A.1 - Amino acids
• GO terms:
  • GO:0040007 - growth (Uniprot)
  • GO:0005576 - extracellular region (Uniprot)
• Reaction(s) (based on iSM810 metabolic model):
  • ATP[c] -> ADP[c] + PI[c] + HIS[c]
  • ATP[c] -> ADP[c] + PI[c] + GLN[c]
• Gene Expression Profile (Transcriptional Responses to Drugs; Boshoff et al, 2004)
• Gene Modules extracted from cluster analysis of 249 transcriptomic datasets using ICA
• Orthologs among selected mycobacteria
• Protein structure:
• Search for Homologs in PDB
• Top 10 Homologs in PDB (as of Nov 2020):
  

  PDB	aa ident	species	PDB title
  6H2T	100%	Mycobacterium tuberculosis H37Rv	GlnH bound to Glu, Mycobacterium tuberculosis
  6H20	100%	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	GlnH bound to Asn, Mycobacterium tuberculosis
  6H1U	100%	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	GlnH bound to Asp, Mycobacterium tuberculosis
  7A99	38%	Thermotoga maritima	Crystal structure of the Phe57Trp mutant of the arginine-bound form of domain 1 from TmArgBP
  6Y16	38%	Thermotoga maritima MSB8	CRYSTAL STRUCTURE OF TMARGBP DOMAIN 1 IN COMPLEX WITH THE GUANIDINIUM ION
  6GPD	38%	Thermotoga maritima MSB8	Crystal structure of the ligand-free form of domain 1 from TmArgBP
  6GPC	38%	Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)	Crystal structure of the arginine-bound form of domain 1 from TmArgBP
  5EYF	35%	Enterococcus faecium DO	Crystal Structure of Solute-binding Protein from Enterococcus faecium with Bound Glutamate

• Links to additional information on glnH:
  • TBDB (updated)
  • Phyre2 structure prediction, model: final.casp.pdb (from Mao et al, 2013)
  • UniProt
  • AlphaFold model
  • Vulnerability = -2.188 (from Jeremy Rock's lab)
  • KEGG - nucleotide and amino acid sequences of gene
  • Mycobrowser
  • PATRIC
  • BioCyc
  • Systems Biology

Amino Acid Sequence

MTRRALLARAAAPLAPLALAMVLASCGHSETLGVEATPTLPLPTPVGMEIMPPQPPLPPDSSSQDCDPTASLRPFATKAEADAAVADIRARGRLIVGLDI
GSNLFSFRDPITGEITGFDVDIAGEVARDIFGVPSHVEYRILSAAERVTALQKSQVDIVVKTMSITCERRKLVNFSTVYLDANQRILAPRDSPITKVSDL
SGKRVCVARGTTSLRRIREIAPPPVIVSVVNWADCLVALQQREIDAVSTDDTILAGLVEEDPYLHIVGPDMADQPYGVGINLDNTGLVRFVNGTLERIRN
DGTWNTLYRKWLTVLGPAPAPPTPRYVD

Additional Information